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Keywords: Reactive oxygen species
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Journal Articles
J Innate Immun (2023) 15 (1): 297–316.
Published Online: 15 November 2022
... LPS, and a mimic of dsRNA, poly(I:C). Mda5 induction is mediated through the production of reactive oxygen species. The induction by IFN-α or LPS occurs at the transcriptional level since the Mda5 mRNA half-life before and after induction is very stable. Interestingly, STAT1 is required for Mda5...
Journal Articles
Journal Articles
J Innate Immun (2022) 14 (6): 657–672.
Published Online: 05 May 2022
... (PGE 2 ) in the gut and subsequently increased Ca 2+ signal to produce reactive oxygen species (ROS) via dual oxidase (Duox). Inhibition of Aa-DSP1 via RNA interference or specific inhibitor treatment failed to increase PGE 2 /Ca 2+ signal upon the bacterial infection. Thus, the inhibitors specifically...
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Journal Articles
Journal Articles
J Innate Immun (2019) 11 (4): 347–358.
Published Online: 09 January 2019
... Reactive oxygen species Reactive nitrogen species National Institutes of Health (NIH) 10.13039/100000002 JournImal omf Inunnaittey Research Article J Innate Immun 2019;11:347 358 DOI: 10.1159/000495472 Received: April 27, 2018 Accepted after revision: November 1, 2018 Published online...
Journal Articles
Journal Articles
J Innate Immun (2018) 10 (5-6): 442–454.
Published Online: 04 April 2018
.... Pseudomonas aeruginosa Klebsiella pneumoniae Biofilm Bacterial adaptation Immune evasion Cystic fibrosis Bacterial infection Inflammasome Pathogen-associated molecular patterns Reactive oxygen species The gram-negative airway pathogens, Pseudomonas aeruginosa and Klebsiella pneumoniae...
Journal Articles
J Innate Immun (2016) 8 (4): 362–373.
Published Online: 08 March 2016
... model, in vivo bioluminescence imaging, neutrophil effector responses and human airway samples, that the chemokine receptor CXCR1 regulates pulmonary host defense against P. aeruginosa . Mechanistically, CXCR1 regulates anti- Pseudomonas neutrophil responses through modulation of reactive oxygen species...
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Journal Articles
Journal Articles
J Innate Immun (2014) 7 (1): 59–73.
Published Online: 24 September 2014
... phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively. PP2 and PRT-060318 also inhibited β-glucan-induced NET formation and reactive oxygen species...
Journal Articles
Journal Articles
J Innate Immun (2009) 1 (6): 592–598.
Published Online: 14 August 2009
... in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate that macrophage-derived ROS also influence phagocytosis and do so by direct and indirect mechanisms. 31 03 2009 30 04...
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Journal Articles
J Innate Immun (2009) 1 (6): 509–526.
Published Online: 07 July 2009
... in macrophage fusion are still not fully understood. In addition to cytokines and a number of adhesion proteins and receptors, it is becoming increasingly clear that NADPH oxidase-generated reactive oxygen species (ROS) also play an important role in macrophage fusion. In this review, we provide an overview...
Journal Articles