... LPS, and a mimic of dsRNA, poly(I:C). Mda5 induction is mediated through the production of reactive oxygen species. The induction by IFN-α or LPS occurs at the transcriptional level since the Mda5 mRNA half-life before and after induction is very stable. Interestingly, STAT1 is required for Mda5...

... Klebsiella to a similar extent as complete Btk deficiency. Neutrophil-specific Btk deficiency abolished extracellular reactive oxygen species production in response to Klebsiella . These data indicate that expression of Btk in neutrophils is crucial, while in B cells, it is dispensable for in vivo host...

... (PGE 2 ) in the gut and subsequently increased Ca 2+ signal to produce reactive oxygen species (ROS) via dual oxidase (Duox). Inhibition of Aa-DSP1 via RNA interference or specific inhibitor treatment failed to increase PGE 2 /Ca 2+ signal upon the bacterial infection. Thus, the inhibitors specifically...

... in a human in vitro system. We found that the apo-ptotic neutrophils enhanced the control of M. tuberculosis in single and HIV-coinfected macrophages, and that this was dependent on myeloperoxidase (MPO) and reactive oxygen species in an autophagy-independent manner. We show that MPO remains active...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Reactive oxygen species Reactive...

... Reactive oxygen species Reactive nitrogen species National Institutes of Health (NIH) 10.13039/100000002 JournImal omf Inunnaittey Research Article J Innate Immun 2019;11:347 358 DOI: 10.1159/000495472 Received: April 27, 2018 Accepted after revision: November 1, 2018 Published online...

... extracellular reactive oxygen species production by fresh PMNs and macrophages. Furthermore, we observed that LMW-Fuc inhibited microparticle release from activated PMN. In vivo experiments showed that circulating PMN-derived microparticles could be detected in mice exposed to bacterial products (LPS/fMLP...

.... Pseudomonas aeruginosa Klebsiella pneumoniae Biofilm Bacterial adaptation Immune evasion Cystic fibrosis Bacterial infection Inflammasome Pathogen-associated molecular patterns Reactive oxygen species The gram-negative airway pathogens, Pseudomonas aeruginosa and Klebsiella pneumoniae...

... model, in vivo bioluminescence imaging, neutrophil effector responses and human airway samples, that the chemokine receptor CXCR1 regulates pulmonary host defense against P. aeruginosa . Mechanistically, CXCR1 regulates anti- Pseudomonas neutrophil responses through modulation of reactive oxygen species...

... of reactive oxygen species. Additionally, LF EMF exposure does not influence autophagy and PAD4 activity. Our study provides a mechanism by which exposure to LF EMFs could influence the innate immune system. lidy.vankemenade@wur.nl 22 12 2014 9 02 2015 10 4 2015 © 2015 S. Karger...

... Macrophage Reactive oxygen species Degranulation Interleukin 22 National Institutes of Health (NIH) 10.13039/100000002 Leishmania braziliensis and L. amazonensis are causative agents of cutaneous leishmaniasis in overlapping endemic areas of South America. Infection by these two...

... phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively. PP2 and PRT-060318 also inhibited β-glucan-induced NET formation and reactive oxygen species...

... priming in response to TNF-α in human PMN and PLB-985 cells, a myeloid cell line differentiated to a neutrophilic phenotype (PLB-D). PMN generated reactive oxygen species (ROS) in response to TNF-α alone, and NADPH oxidase activity increased in response to stimulation with formyl-Met-Leu-Phe after priming...

... in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate that macrophage-derived ROS also influence phagocytosis and do so by direct and indirect mechanisms. 31 03 2009 30 04...

...Bin Li; Karen Bedard; Silvia Sorce; Boris Hinz; Michel Dubois-Dauphin; Karl-Heinz Krause Reactive oxygen species (ROS) generation by microglia is implicated in neuroinflammation and neurotoxicity, as well as in host defense, cell proliferation and excitatory amino acid release. Recent studies...

... in macrophage fusion are still not fully understood. In addition to cytokines and a number of adhesion proteins and receptors, it is becoming increasingly clear that NADPH oxidase-generated reactive oxygen species (ROS) also play an important role in macrophage fusion. In this review, we provide an overview...

... oxidase enzymes (Nox1–Nox5, Duox1 and 2) generate reactive oxygen species (ROS) as components of the host innate immune response to bacteria, including Nox1 in gastrointestinal epithelial tissues. We show that ETx effectively inhibits ROS formation by Nox1 in HT-29 colon epithelial cells. This inhibition...