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Keywords: Reactive oxygen species
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Journal Articles
J Innate Immun (2023) 15 (1): 297–316.
Published Online: 15 November 2022
... LPS, and a mimic of dsRNA, poly(I:C). Mda5 induction is mediated through the production of reactive oxygen species. The induction by IFN-α or LPS occurs at the transcriptional level since the Mda5 mRNA half-life before and after induction is very stable. Interestingly, STAT1 is required for Mda5...
Journal Articles
Journal Articles
J Innate Immun (2022) 14 (6): 657–672.
Published Online: 05 May 2022
... (PGE 2 ) in the gut and subsequently increased Ca 2+ signal to produce reactive oxygen species (ROS) via dual oxidase (Duox). Inhibition of Aa-DSP1 via RNA interference or specific inhibitor treatment failed to increase PGE 2 /Ca 2+ signal upon the bacterial infection. Thus, the inhibitors specifically...
Journal Articles
Journal Articles
J Innate Immun (2019) 11 (3): 216–226.
Published Online: 03 April 2019
... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Reactive oxygen species Reactive...
Journal Articles
J Innate Immun (2019) 11 (4): 347–358.
Published Online: 09 January 2019
... Reactive oxygen species Reactive nitrogen species National Institutes of Health (NIH) 10.13039/100000002 JournImal omf Inunnaittey Research Article J Innate Immun 2019;11:347 358 DOI: 10.1159/000495472 Received: April 27, 2018 Accepted after revision: November 1, 2018 Published online...
Journal Articles
Journal Articles
J Innate Immun (2018) 10 (5-6): 442–454.
Published Online: 04 April 2018
... formation of extracellular polysaccharides. c-di-GMP coordinates biofilm formation and bacterial motility, switching from flagellar- to a pilus-dependent twitching motility through activation of the PiY1/chpAK complex. Both endogenous/exogenous reactive oxygen species (ROS) sources and catabolite repressor...
Journal Articles
J Innate Immun (2016) 8 (4): 362–373.
Published Online: 08 March 2016
... model, in vivo bioluminescence imaging, neutrophil effector responses and human airway samples, that the chemokine receptor CXCR1 regulates pulmonary host defense against P. aeruginosa . Mechanistically, CXCR1 regulates anti- Pseudomonas neutrophil responses through modulation of reactive oxygen species...
Journal Articles
Journal Articles
Journal Articles
J Innate Immun (2014) 7 (1): 59–73.
Published Online: 24 September 2014
... phosphorylation of Src family kinases and Syk that were suppressed by the Src family inhibitor 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3, 4-d] pyrimidine (PP2) and a novel Syk inhibitor, PRT-060318, respectively. PP2 and PRT-060318 also inhibited β-glucan-induced NET formation and reactive oxygen species...
Journal Articles
Journal Articles
J Innate Immun (2009) 1 (6): 592–598.
Published Online: 14 August 2009
... in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate that macrophage-derived ROS also influence phagocytosis and do so by direct and indirect mechanisms. 31 03 2009 30 04...
Journal Articles
Journal Articles
J Innate Immun (2009) 1 (6): 509–526.
Published Online: 07 July 2009
... in macrophage fusion are still not fully understood. In addition to cytokines and a number of adhesion proteins and receptors, it is becoming increasingly clear that NADPH oxidase-generated reactive oxygen species (ROS) also play an important role in macrophage fusion. In this review, we provide an overview...
Journal Articles
J Innate Immun (2009) 1 (2): 145–152.
Published Online: 18 August 2008
... oxidase enzymes (Nox1–Nox5, Duox1 and 2) generate reactive oxygen species (ROS) as components of the host innate immune response to bacteria, including Nox1 in gastrointestinal epithelial tissues. We show that ETx effectively inhibits ROS formation by Nox1 in HT-29 colon epithelial cells. This inhibition...