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Keywords: Pneumococcal pneumonia
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Journal Articles

IL-37 Causes Excessive Inflammation and Tissue Damage in Murine Pneumococcal Pneumonia

Available to Purchase
Subject Area:
Further Areas , Immunology and Allergy , Pathology and Cell Biology
Anja E. Schauer, Tilman E. Klassert, Carolin von Lachner, Diana Riebold, Anne Schneeweiß, Magdalena Stock, Mario M. Müller, Sven Hammerschmidt, Philip Bufler, Ulrike Seifert, Kristina Dietert, Charles A. Dinarello, Marcel F. Nold, Achim D. Gruber, Claudia A. Nold-Petry, Hortense Slevogt
Journal: Journal of Innate Immunity
J Innate Immun (2017) 9 (4): 403–418.
https://doi.org/10.1159/000469661
Published Online: 10 June 2017
... identified that IL-37 modulates several core components of a successful inflammatory response to pneumococcal pneumonia, which lead to increased inflammation, tissue damage, and mortality. S. pneumoniae WT D39 serotype 2 (encapsulated) and the isogenic nonencapsulated D39∆ cps was a kind gift from...
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Journal Articles

Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by Streptococcus Pneumoniae

Available to Purchase
Subject Area:
Further Areas , Immunology and Allergy , Pathology and Cell Biology
Dana C. Blok, Miriam H.P. van Lieshout, Arie J. Hoogendijk, Sandrine Florquin, Onno J. de Boer, Cecilia Garlanda, Alberto Mantovani, Cornelis van't Veer, Alex F. de Vos, Tom van der Poll
Journal: Journal of Innate Immunity
J Innate Immun (2014) 6 (4): 542–552.
https://doi.org/10.1159/000358239
Published Online: 14 February 2014
... role in the host defense against infection. In this study, we sought to determine the role of single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR a.k.a. TIR8), a negative regulator of TLR signaling, in pneumococcal pneumonia and sepsis . Wild-type and SIGIRR-deficient ( sigirr...
View articletitled, Single Immunoglobulin Interleukin-1 Receptor-Related Molecule Impairs Host Defense during Pneumonia and Sepsis Caused by Streptococcus Pneumoniae
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