... otitis media (OM) mouse model. Wild-type C57BL/6 (WT) and SP-D knockout (KO) mice were used in this study. Mice were injected in the middle ear (ME) with 5 μL of NTHi bacterial solution (3.5 × 10 5 CFU/ear) or with the same volume of sterile saline (control). Mice were sacrificed at 3 time points, days 1...

...Eric A. Jones; Glen McGillivary; Lauren O. Bakaletz Biofilms formed by nontypeable Haemophilus influenzae (NTHI) are associated with multiple chronic infections of the airway, including otitis media. Extracellular DNA (eDNA) is part of the biofilm matrix and serves as a structural component. Human...

...Glen McGillivary; Zachary B. Jordan; Mark E. Peeples; Lauren O. Bakaletz Respiratory syncytial virus (RSV) is an important viral pathogen of otitis media, bronchiolitis, and pneumonia. As infection of the upper airways is a precondition for the development of these diseases, understanding RSV...

...Wenzhou Hong; Richard A. Juneau; Bing Pang; W. Edward Swords Nontypeable Haemophilus influenzae (NTHi) is a leading cause of acute and chronic otitis media, which are a major public health problem worldwide. The persistence of NTHi during chronic and recurrent otitis media infections involves...