... Neutrophil extracellular traps Immunotherapy [email protected] [email protected] 16 09 2023 27 11 2023 15 01 2024 © 2024 The Author(s). Published by S. Karger AG, Basel Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative...

...Martin Maronek; Roman Gardlik Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically, NETs may...

..., including (i) gut-leakage; FITC-dextran assay and serum (1→3)-β-D-glucan (BG), (ii) systemic inflammation (serum cytokines), and (iii) neutrophil extracellular traps (NETs); gene expression of peptidyl arginase 4 ( PAD4 ) and IL-1β , nuclear morphology staining by 4′,6-diamidino-2-phenylindole (DAPI) and co...

...Nicole de Buhr; Ann Christin Parplys; Maria Schroeder; Timo Henneck; Berfin Schaumburg; Stephanie Stanelle-Bertram; Dominik Jarczak; Axel Nierhaus; Jens Hiller; Sven Peine; Stefan Kluge; Karin Klingel; Gülsah Gabriel; Maren von Köckritz-Blickwede Neutrophil extracellular traps (NETs) have been...

... of such communication is not fully understood. Activated neutrophils are known to release DNA-containing extracellular traps (neutrophil extracellular traps [NETs]) and, based on the known ability of tryptase to interact with negatively charged polymers, we here hypothesized that tryptase might interact with NET...

...Ariane Neumann; Praveen Papareddy; Johannes Westman; Ole Hyldegaard; Johanna Snäll; Anna Norrby-Teglund; Heiko Herwald The formation of neutrophil extracellular traps (NETs) is a host defence mechanism, known to facilitate the entrapment and growth inhibition of many bacterial pathogens. It has...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2017 Neutrophil extracellular traps Monosodium urate crystals Uric acid Cigarette smoke Human epithelial cells The lungs are continuously exposed to exogenous...

...Jonatan Leffler; Zoltán Prohászka; Bálint Mikes; György Sinkovits; Katarzyna Ciacma; Péter Farkas; Marienn Réti; Kata Kelen; György S. Reusz; Attila J. Szabó; Myriam Martin; Anna M. Blom Background: Neutrophil extracellular traps (NETs) can stimulate thrombosis, and their degradation is decreased...

... cells are suggested as possible target cells, though a clear mechanism is lacking. Considering their crucial role in innate immune activation, we selected an ex vivo exposure set-up with human neutrophils to investigate a possible correlation between neutrophil extracellular trap (NET) formation and LF...

...Sara Nanì; Laura Fumagalli; Uma Sinha; Lynn Kamen; Patrizia Scapini; Giorgio Berton We report that particles of β-glucan, one of the surface components of yeasts, are powerful inducers of neutrophil extracellular trap (NET) formation in human neutrophils. β-Glucan triggered a prolonged...

...Ariane Neumann; Lena Völlger; Evelien T.M. Berends; E. Margo Molhoek; Daphne A.C. Stapels; Marika Midon; Ana Friães; Alfred Pingoud; Suzan H.M. Rooijakkers; Richard L. Gallo; Matthias Mörgelin; Victor Nizet; Hassan Y. Naim; Maren von Köckritz-Blickwede Neutrophil extracellular traps (NETs) have...

... the colonizing pathogens. Here, we investigated the molecular composition of non-mucoid and mucoid Pseudomonas aeruginosa -induced neutrophil extracellular traps (NETs) in vitro and compared them to the DNA-protein complexes present in the CF sputum. The protein composition of P. aeruginosa -induced NET...

... for the first time that an antibiotic, namely the fluoroquinolone enrofloxacin, enhances the formation of bovine neutrophil extracellular traps (NETs). Pharmacologically inactivated NADPH oxidase or peptidyl-arginine deiminase-4 distinctly reduced enrofloxacin-induced NET formation. Additionally, when cells...

... systemic infections even in previously healthy individuals, thereby reflecting a resistance to effective neutrophil clearance. The recent discovery of neutrophil extracellular traps (NETs) has opened a novel dimension in our understanding of how these specialized leukocytes kill pathogens. NETs consist...

...Daniela B. Munafo; Jennifer L. Johnson; Agnieszka A. Brzezinska; Beverly A. Ellis; Malcolm R. Wood; Sergio D. Catz Neutrophils kill bacteria on extracellular complexes of DNA fibers and bactericidal proteins known as neutrophil extracellular traps (NETs). The NET composition and the bactericidal...

... microorganisms by phagocytosis, neutrophils can also kill microbes by capturing them in extracellular structures consisting of granule proteins and DNA called neutrophil extracellular traps (NETs). This review summarizes the recent advancements regarding the structure, production and biological relevance of NETs...