... with respect to blood and immune cell development and function in comparison to wild-type zebrafish. Results: The Stat3 KO mutant showed perturbation of hematopoietic lineages throughout primitive and early definitive hematopoiesis. Neutrophil numbers did not increase in response to lipopolysaccharide (LPS...

...Na Rong; Xiaohui Wei; Jiangning Liu Background: Neutrophils are the first line of defense against pathogens. They are divided into multiple subpopulations during development and kill pathogens through various mechanisms. Neutrophils are considered one of the markers of severe COVID-19. Summary...

...Hang Zhao; Wenhua Li; Xin Zhou; Liang Pan; Yun Feng; Pingyu Gao; Jie Ji; Huanyan Zhang; Kai Zhao; Chi Wang; Zhanjun Lu Introduction: C-X-C motif chemokine ligand 1 (CXCL1) is a potent neutrophil chemoattractant that plays a pivotal role in recruiting neutrophils during inflammatory conditions...

... to in the content or advertisements. 2023 Staphylococcus aureus Biofilm Immunometabolism Macrophage Myeloid-derived suppressor cell Neutrophil NIH Staphylococcus aureus ( S. aureus ) is a common human commensal and significant opportunistic pathogen. Approximately 30% of humans...

..., the serum complement system and phagocytic leukocytes (e.g., neutrophils) are highly effective at eliminating K. pneumoniae and thereby preventing severe disease. On the other hand, the microbe is a major cause of healthcare-associated infections, especially in individuals with underlying susceptibility...

... with human lactoferrin (hLf) reduces UPEC epithelial adherence and enhances neutrophil antimicrobial functions including bacterial killing and extracellular trap production. Notably, a single intravesicular dose of hLf drastically reduced bladder bacterial burden and neutrophil infiltration in our murine UTI...

.... For example, anti-inflammatory MФs are biased towards oxidative phosphorylation whereas proinflammatory MФs favor aerobic glycolysis. This review will compare the immune responses elicited by planktonic and biofilm bacterial infections, with a discussion on the metabolic properties of MФs and neutrophils...

...Simon M. Chatfield; Nathalie Thieblemont; Véronique Witko-Sarsat Research into neutrophil biology in the last 10 years has uncovered a number of unexpected aspects of this still mysterious innate immune cell. Advances in technology have allowed visualisation of neutrophil trafficking to sites...

...Scott D. Kobayashi; Natalia Malachowa; Frank R. DeLeo Neutrophils are an important component of the innate immune system and provide a front line of defense against bacterial infection. Although most bacteria are killed readily by neutrophils, some bacterial pathogens have the capacity...

... response differ considerably depending on the infecting parasite species. The mechanisms underlying these differences appear to be multifactorial, with both host and parasite components contributing to disease outcome. As neutrophils are a prominent component of the inflammatory infiltrate in chronic...

... thereafter. The mechanism of innate immune defects included a reduced leak of albumin into the lungs together with reduced levels of tumor necrosis factor in bronchoalveolar lavage fluids and increased levels of interleukin-10 that were persistent. Bone marrow-derived neutrophils (polymorphonuclear...

...Clara Braian; Valentin Hogea; Olle Stendahl Neutrophils activated by Mycobacterium tuberculosis (Mtb) form neutrophil extracellular traps (NETs), containing DNA and several biologically active cytosolic and granular proteins. These NETs may assist in the innate immune defense against different...

...Jochen Grommes; Maik Drechsler; Oliver Soehnlein Recruitment of neutrophils, regarded as a key mechanism in acute lung injury (ALI), is orchestrated by cell adhesion molecules and chemokines. While the importance of cell adhesion molecules has been carefully investigated, little is known about...

... atheroprogression and its clinical complications. Here, we review the important role of classical monocytes in atheroprogression as well as their routes of arterial recruitment. We specifically highlight the role of cell adhesion molecules as well as of platelet-derived chemokines and neutrophil-borne alarmins...

...Jan Rossaint; Alexander Zarbock The recruitment of immune cells is crucial for the development of inflammatory processes. The classical recruitment cascade of neutrophils into inflamed tissues is well understood and consists of capturing, rolling, slow rolling, arrest, postadhesion strengthening...

...Justin T. Schwartz; Sarmistha Bandyopadhyay; Scott D. Kobayashi; Jenna McCracken; Adeline R. Whitney; Frank R. DeLeo; Lee-Ann H. Allen We demonstrated recently that Francisella tularensis profoundly impairs human neutrophil apoptosis, but how this is achieved is largely unknown. Herein we used...

...Andreas Cederlund; Birgitta Agerberth; Peter Bergman Neutrophil-derived antimicrobial peptides and proteins (AMPs) play an important role in the defense against microbes. Absence of defense is illustrated by neutropenic patients with frequent bacterial and fungal infections. However...

...Sandra Moriceau; Gérard Lenoir; Véronique Witko-Sarsat Cystic fibrosis (CF) is a chronic inflammatory lung disease characterized by polymorphonuclear neutrophil (PMN)-dominated airway inflammation. Defective apoptosis might explain PMN persistence at these inflammation sites. We previously reported...

...Robin van Bruggen; Agata Drewniak; Anton T.J. Tool; Machiel Jansen; Michel van Houdt; Judy Geissler; Timo K. van den Berg; Helen Chapel; Taco W. Kuijpers Human neutrophils were found to express all known Toll-like receptors (TLRs) except TLR3 and TLR7. IRAK-4-deficient neutrophils were tested...

... activities when released from the cell surface. Here we identify a novel role of M1 protein in the stimulation of neutrophil and mast cell extracellular trap formation, yet also subsequent survival of the pathogen within these DNA-based innate defense structures. Targeted mutagenesis and heterologous...