... persistent innate immune responses remain obscure. In this study, we induce long-term systemic immune activation in Drosophila through genetic manipulation. Then, the dynamic pattern of LDs is traced in the Drosophila fat body. We find that deficiency of Plin1, a key regulator of LDs’ reconfiguration, blocks...

...Yanmin Lyu; Tianyu Wang; Shuhong Huang; Zhaoqiang Zhang The innate immune system, as the host’s first line of defense against intruders, plays a critical role in recognizing, identifying, and reacting to a wide range of microbial intruders. There is increasing evidence that mitochondrial stress...

...Tisheng Shan; Yang Wang; Neal T. Dittmer; Michael R. Kanost; Haobo Jiang The melanization and Toll pathways, regulated by a network of serine proteases and noncatalytic serine protease homologs (SPHs), have been investigated mostly in adult and larval insects. However, how these innate immune...

... to in the content or advertisements. 2022 Alphavirus Interferon Neuron Innate immunity Central nervous system (CNS) virus infections are a significant global public health burden [ 1 ]. Arthropod-borne viruses (arboviruses), mainly the RNA alphaviruses and flaviviruses, are responsible...

... defense against K. pneumoniae . Bruton’s tyrosine kinase Klebsiella pneumoniae Innate immunity Neutrophils Reactive oxygen species Bruton’s tyrosine kinase (Btk) is a member of the family of nonreceptor tyrosine kinases designated “tyrosine kinase expressed in hepatocellular carcinoma”. Btk...

... toxins of prokaryotic origin, were expressed at high level, which may be important for parasitoid elimination. Our results reveal coordinated molecular and structural changes in the course of MGH differentiation and parasitoid encapsulation, providing a mechanistic model for a powerful innate immune...

... of transcription factor hypoxia-inducible factor 1 alpha (HIF-1α), widely recognized as a regulator of immune activation during infection, in the host response to GBS. Given the importance of endogenous HIF-1α for innate immune defense, and the potential utility of HIF-1α stabilization in promoting bacterial...

... to in the content or advertisements. Fibrosis Antimicrobial peptides Insect immunity Innate immunity Extracellular matrix Extracellular matrices (ECMs) are highly specialized three-dimensional, tissue- and stage-specific structures, which surround cells. Much of our understanding of the ECM...

..., or vesicular stomatitis virus, or by treatment of poly(I:C) and IFN-β. Furthermore, loss of innate immune adaptor IPS-1 or receptor IFNAR1 resulted in lower induction levels of several lncRNAs by ZIKV. Overexpression of 3 lncRNAs (RPL27-OT1, OASL-IT1, and REC8-OT3) reduced the virus yields of ZIKV. Knockout...

... condition that can lead to adverse pregnancy outcomes for the mother and fetus as well as severe long-term neonatal morbidities. Despite much research focused on the consequences of intra-amniotic infection, there remains little knowledge about the innate immune cells that respond to invading microbes. We...

...Wenxin Wu; Jordan P. Metcalf The important role of interferons (IFNs) in antiviral innate immune defense is well established. Although recombinant IFN-α was approved for cancer and chronic viral infection treatment by regulatory agencies in many countries starting in 1986, no IFNs are approved...

...) 10.13039/100000002 Siglec Interleukin-1β Caspase-1 Inflammasome Macrophages Innate immunity Vimentin © 2019 The Author(s) Published by S. Karger AG, Basel 2019 Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative Commons Attribution...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Innate immunity Cytokines Gender Sex Lipopolysaccharide Blood Fig. 1. Forest plots of the ratios of men...

... model. We propose that lactoferrin is an important modulator of innate immune responses in the urinary tract and has potential application in novel therapeutic design for UTI. vnizet@ucsd.edu 12 12 2018 26 02 2019 3 5 2019 © 2019 The Author(s) Published by S. Karger AG...

..., instructions or products referred to in the content or advertisements. Anopheles stephensi Dual oxidase Midgut Plasmodium Innate immunity Thioester-containing protein 1 Malaria JournImal omf Inunnaittey Research Article J Innate Immun 2019;11:496 505 DOI: 10.1159/000497417 Received: September...

... aeruginosa to sense bacterial population density and fitness, and regulate virulence, biofilm development, metabolite acquisition, and mammalian host defense. We also focus on the role of N -acylhomoserine lactone-dependent QS signaling in the modulation of innate immune responses connected together via...

...Gertrude O. Oppong-Nonterah; Omar Lakhdari; Asami Yamamura; Hal M. Hoffman; Lawrence S. Prince Early exposure to inflammatory signals may have a lasting impact on immune function. Present throughout embryogenesis, macrophages are key cells providing innate immune protection to the developing fetus...

...Maxwell T. Hincke; Mylène Da Silva; Nicolas Guyot; Joël Gautron; Marc D. McKee; Rodrigo Guabiraba-Brito; Sophie Réhault-Godbert The integrated innate immune features of the calcareous egg and its contents are a critical underpinning of the remarkable evolutionary success of the Aves clade...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Bacterial biofilm Macrophage Myeloid-derived suppressor cell Neutrophil Innate immunity Immunometabolism...

... exchange. An important component of innate immunity for identifying viruses is the family of C-type collagen-containing lectins, also known as collectins. These secreted, soluble proteins are pattern recognition receptors (PRRs) which recognise pathogen-associated molecular patterns (PAMPs), including...