...Leon Cyranka; Ida Mariegaard; Mikkel-Ole Skjødt; Rafael Bayarri-Olmos; Tom Eirik Mollnes; Peter Garred; Anne Rosbjerg Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular...

... of hsa_circ_0102678 in regulating inflammation of acne. Methods: First, microarray analysis was performed to study the expression of circRNAs in acne. Subsequently, RNase R digestion assay and fluorescence in situ hybridization assay were utilized to confirm the characteristics of hsa_circ_0102678. Finally, qRT-PCR...

... regulation Inflammation Reactive oxygen species Melanoma differentiation-associated protein 5 (MDA5) is part of the RIG-I-like receptor family and is an important cytosolic sensor of viral RNA, inducing the production of type I interferons (IFNs) [ 1‒4 ]. MDA5 plays a critical role in viral...

... inflammation, which captures hallmarks of both hyperinflammation and immunological tolerance. Therefore, 110 healthy volunteers were intravenously challenged with 1 ng/kg LPS twice: on day 0 to determine the extent of the IV (hyper)inflammatory response and on day 7 to determine the degree of IV endotoxin...

... and inflammatory markers in COVID-19 patients, underscoring a possible role of MASP-2 in COVID-19 pathophysiology. Peter.Garred@regionh.dk Mannose-binding lectin-associated serine protease 2 MASP-2 Assay COVID-19 Inflammation Outcome The complement system is an important part of innate...

... of anti-DNA autoantibodies. Accelerated systemic inflammation was found in association with a relatively mild renal phenotype. Splenocytes of phenotypically overall-normal Gdf15−/− C57BL/6 and lupus-prone C57BL/6 lpr/lpr mice displayed increased in vitro lymphoproliferative responses or interferon...

... lung injury Inflammation Extracellular vesicles Polyunsaturated fatty acids Macrophage National Institutes of Health (NIH) 10.13039/100000002 The pathophysiology of acute lung injury (ALI) and a severe form of ALI, acute respiratory distress syndrome (ARDS), is orchestrated...

... of mechanical ventilation (MV) and 30-day mortality compared with clinical parameters and other markers of inflammation were assessed by logistic regression analysis and expressed as odds ratio (OR) with 95% confidence interval (CI). Analyses were repeated in a prospective validation cohort ( n = 112...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Inflammation Metabolism Trained immunity Non-alcoholic fatty liver disease Obesity Adipose tissue Macrophages Immunometabolism In the last two decades...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Macrophage Inflammation Macrophage polarization Interleukin-10 Under...

...Marina Nati; Kyoung-Jin Chung; Triantafyllos Chavakis Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and is linked to obesity and related conditions, such as the metabolic syndrome. When hepatic steatosis is accompanied by inflammation, the disorder...

...Mandy Menzel; Hamid Akbarshahi; Irma Mahmutovic Persson; Cecilia Andersson; Manoj Puthia; Lena Uller Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling...

.... Metabolism Inflammation Insulin Cancer Macrophage Obesity Diabetes Macrophages are present in all tissues and devoted to maintain tissue integrity, homeostasis, and balance. They constitute a cell population of diverse origin since they arise from distinct cell lineages during embryonic...

...Chen Jiang; Weilin Fang; Tingting Lv; Yinjun Gu; Jianwei Lv Interstitial cystitis is associated with neurogenic inflammation and neuropathic bladder pain. Dual leucine zipper kinase (DLK) expressed in sensory neurons is implicated in neuropathic pain. We hypothesized that neuronal DLK is involved...

... monocytes/macrophages (Ly6C +ve, CD11b +ve) in the liver as detected by Western blot and flow cytometry, respectively. In conclusion, a proof of concept for inflammation attenuation of BAM15 through metabolic interference-induced anti-inflammation on macrophages and hepatocytes was demonstrated as a new...

..., instructions or products referred to in the content or advertisements. Interleukin-27 Toll-like receptor 7 Toll-like receptor 8 Toll-like receptor Interferon Monocytes Macrophages Inflammation Innate immune cells, such as monocytes and macrophages, express Toll-like receptors (TLRs), which...

... Inflammation Mast cells Mast cells (MCs) are multifaceted effector cells of the immune system [ 1-5 ]. They are widely distributed in the body but are particularly abundant in tissues that are portals of entry for external insults. MCs are equipped with a broad range of sensors that enable...

... to in the content or advertisements. Streptococcus agalactiae Group B streptococcus Pigment Hemolysis Coagulation Inflammation Streptococcal toxic shock syndrome (STSS) is typically caused by Streptococcus pyogenes (group A streptococcus [GAS]). Reports of septic shock and multiorgan...

... obstructive pulmonary disease Animal models Treatment Fibrosis Inflammation Chronic obstructive pulmonary disease (COPD) is a disease syndrome characterized by an inflammatory airway state induced by environmental stimuli, primarily tobacco smoke and household or industrial air pollution [ 1-3...

... and on complement-mediated inflammation. © 2019 The Author(s) Published by S. Karger AG, Basel 2019 Open Access License / Drug Dosage / Disclaimer This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution...