... have been implicated in host defense against UTI based on their potent antimicrobial activity toward uropathogens and increased UTI susceptibility in AMP-deficient mice [ 13‒18 ]. Multiple innate immune cell types produce AMPs, including urothelial cells of the lower urinary tract, principal...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Antimicrobial peptides Bacterial infection Macrophage Host defense...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2022 Staphylococcus aureus Host defense Human group IIA-secreted phospholipase A2 Daptomycin Lipoprotein Infectious diseases are a significant cause of morbidity...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Host defense Keratinocytes Aryl hydrocarbon receptor Staphylococcus aureus Deutsche Foschungsgemeinschaft (DFG) 10.13039/501100001659 Staphylococcus aureus...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Zaprionus indianus Hemocyte Multinucleated Encapsulation Drosophila Host defense...

...Jasmijn A. Schrumpf; Dennis K. Ninaber; Anne M. van der Does; Pieter S. Hiemstra Airway epithelium is an important site for local vitamin D (VD) metabolism; this can be negatively affected by inflammatory mediators. VD is an important regulator of respiratory host defense, for example...

...Theodora A.M. Claushuis; Alex F. de Vos; Joris J.T.H. Roelofs; Onno J. de Boer; Cornelis van ’t Veer; Tom van der Poll Platelet-dense (δ) granules are important for platelet function. Platelets contribute to host defense and vascular integrity during pneumonia and sepsis, and δ granule products...

..., instructions or products referred to in the content or advertisements. Checkpoint inhibitors Hepatic stellate cell Host defense Kupffer cell Liver sinusoidal endothelial cells Macrophages Pathogen-associated molecular patterns Pattern recognition receptors Primary cells Primary human hepatocytes...

... peptides Bomanins Drosophila Effector Host defense NF-κB Toll receptor National Institutes of Health (NIH) 10.13039/100000002 4 04 2018 6 05 2018 19 6 2018 © 2018 S. Karger AG, Basel 2018 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved...

... that contribute significantly to the host defense against invading microbes [ 3, 4 ]. For example, individuals with complement deficiencies are more susceptible to recurrent bacterial infections than people with a fully functional complement system [ 4, 5 ]. The complement membrane attack complex (C5b-C9) forms...

... Contact activation Factor H Host defense Kallikrein The plasma contact activation system is part of the innate immune system [ 1 ] and is activated spontaneously by negatively charged surfaces (e.g., bacterial or fungal surfaces) and by polyphosphates or orthophosphates released by platelets...

... tested under each experimental condition. Host defense Immune response Kinase Phosphatase Protein Sepsis National Institutes of Health (NIH) 10.13039/100000002 Severe traumatic injury is often complicated by nosocomial infection and organ failure. Together...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Inflammation Inflammasome Pneumonia Innate immunity Host defense Pseudomonas aeruginosa Pseudomonas...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Antimicrobial peptides Epithelium Host defense Chronic obstructive pulmonary disease Cigarette smoke Chronic...

... immune system is an evolutionarily conserved host defense system with key features being shared between plants, invertebrates, and mammals [ 1, 2 ]. Innate immune defenses in mammals encompass virtually all tissues, particularly barrier surfaces such as the skin or the mucosal surfaces of the respiratory...

... inflammation is good or bad in CF and how innate immune mechanisms could be harnessed therapeutically. Cystic fibrosis Lung disease Host defense Immune response Pattern recognition receptors Toll-like receptor Neutrophils • When should inflammation be targeted? At first glance, the earlier...

.... Complement Host defense Neutrophils Phagocytosis Aspergillus species are saprophytic fungi that are globally distributed and amongst the most common molds encountered. The genus Aspergillus includes over 200 different species, of which only a small number is associated with human or animal...

..., instructions or products referred to in the content or advertisements. Comparative immunology Drosophila Encapsulation Granuloma Host defense Immune responses Insects Multinucleated giant hemocytes Parasitology Granuloma formation and the encapsulation reaction are typical responses...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Host defense Pattern recognition receptors Virology However, most of the estimated 160 million people worldwide infected by HCV do not clear the virus but develop...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cytokines Host defense Macrophages Phagocytosis Influenza virus and Streptococcus pneumoniae are the two...