... reduced AMP expression in the epithelium contributes to this lower defense is largely unknown. We investigated the bacterial killing activity and expression of AMPs by air-liquid interface-cultured primary bronchial epithelial cells from COPD patients and non-COPD (ex-)smokers that were stimulated...

... in the epithelium both under physiological conditions and upon bacterial infection. To this end, we examined the distribution of the MCPIP-1 transcript and protein in various tissues. The MCPIP-1 protein level was higher in epithelial cells than in myeloid cells. MCPIP-1 exerted RNase activity towards...

..., instructions or products referred to in the content or advertisements. Interferon-λ IL28B Polymorphism Single-nucleotide polymorphism Hepatitis C virus Autoimmunity Cytokines Epithelium Host defence Immune response Virology The host response to infection is complex, and whilst...

... epithelium [ 16 ]. Contribution of IFN-λ was much clearer in the case of respiratory syncytial virus [ 15 ]. Indeed, control of respiratory syncytial virus infection depended equally on the presence of type I and type III IFN receptors. Interestingly, IFN-λ was shown to play a major, nonredundant, role...

...R. Lutfi; J.R. Ledford; P. Zhou; I.P. Lewkowich; K. Page Mucosal dendritic cells (DC) are intimately associated with the airway epithelium and thus are ideally situated to be first responders to pathogens. We hypothesize that DC drive innate immune responses through early release of tumor necrosis...

.... Autoimmunity Epithelium Host defense Immune response Pathogen-associated molecular patterns Pattern recognition receptors Toll-like receptor Skin In other skin disorders, the evidence for a role of PRRs is still more speculative, although it may have important implications. We will mention three...

..., dysplastic and malignant esophageal squamous epithelium. Methods: TLR9 expression was analyzed by immunohistochemistry in 46 cases of esophageal squamous cell carcinoma, including 12 cases with adjacent squamous dysplasia and 24 cases with normal esophageal epithelium. TLR9 expression was compared with tumor...