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Keywords: Diamide
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Journal Articles

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

Subject Area:
Further Areas , Immunology and Allergy , Pathology and Cell Biology
Sandra Moriceau, Gérard Lenoir, Véronique Witko-Sarsat
Journal: Journal of Innate Immunity
J Innate Immun (2010) 2 (3): 260–266.
https://doi.org/10.1159/000295791
Published Online: 10 March 2010
... heterozygotes for the CFTR mutation but without chronic bacterial infection. They also demonstrated delayed PMN apoptosis compared with healthy controls, as assessed by annexin-V labeling and caspase-3 cleavage. Diamide, a direct thiol-oxidizing agent, potentiated PMN apoptosis in controls and CF patients...
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