...A. Menendez; B.P. Willing; M. Montero; M. Wlodarska; C.C. So; G. Bhinder; B.A. Vallance; B.B. Finlay Paneth cell α-defensins are antimicrobial peptides involved in the control of the intestinal microbiota and immunological homeostasis. In mice, they are encoded by multiple, highly homologous genes...

...Jian Ding; Aprille Rapista; Natalia Teleshova; Wuyuan Lu; Mary E. Klotman; Theresa L. Chang Defensins are highly abundant antimicrobial peptides in the female genital mucosa. We have previously shown that human defensins 5 and 6 (HD5 and HD6), produced by cervicovaginal epithelial cells...

..., and elevated cytokine levels indicated inflammatory activation. Levels of bactericidal/permeability-increasing protein, heparin-binding protein, α-defensins and lactoferrin but not LL-37 were elevated in sepsis patients compared with controls. Bactericidal/permeability-increasing protein levels correlated...

...Chisato Ishikawa; Hiroki Tanabe; Atsuo Maemoto; Takahiro Ito; Jiro Watari; Toru Kono; Mikihiro Fujiya; Toshifumi Ashida; Tokiyoshi Ayabe; Yutaka Kohgo Human defensin-5 (HD-5) is one of the major antimicrobial peptides secreted by Paneth cells in the human small intestine. HD-5 is produced...

...Jian Ding; Yi-Ying Chou; Theresa L. Chang Defensins are antimicrobial peptides important to innate host defense. In addition to their direct antimicrobial effect, defensins modulate immune responses. Increasing evidence indicates that defensins exhibit complex functions by positively or negatively...

...M.D. Carlisle; R.N. Srikantha; K.A. Brogden Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide α-defensins...