...: The complement system’s alternative pathway relies on factor H (FH) for immune homeostasis. Next to FH, a group of highly similar proteins was described known as the FH-related (FHR) proteins. The FH protein family includes FH, factor H-like protein 1, and five FHR proteins (FHR-1 to -5). The exact function...

... activation is consistently active, keeping the complement system primed for immediate response. This constant “tick-over” mechanism is regulated by the factor H (FH) protein family, which encompasses seven highly related proteins: FH, FHL-1, and five FH-related (FHR-1 to -5) proteins. The current model...

... in immunocompromised hosts. The complement system is a critical mechanism of innate immunity that protects the human body from bacterial infections. Complement activation leads to the deposition of the membrane attack complex (MAC), which can directly lyse gram-negative bacteria. However, A. baumannii has developed...

...Leon Cyranka; Ida Mariegaard; Mikkel-Ole Skjødt; Rafael Bayarri-Olmos; Tom Eirik Mollnes; Peter Garred; Anne Rosbjerg Introduction: The complement system anaphylatoxin C5a is a critical player in inflammation. By binding to complement C5a receptor 1 (C5aR1/CD88), C5a regulates many cellular...

... Baas Damage and disease of nerves activates the complement system. We demonstrated that activation of the terminal pathway of the complement system leads to the formation of the membrane attack complex (MAC) and delays regeneration in the peripheral nervous system. Animals deficient in the complement...

...- and intraspecies vaccine designs. In this section, we will discuss the use of CEPs as vaccine components (summarized in Table  3 ). Bacterial infection Cell-envelope protease Chemoattractants Complement system Streptococcus Wellcome Trust 10.13039/100010269 Successful host...

... Complement system Keratinocytes Pattern recognition receptors The complement system acts as an efficient danger-sensing system, protecting the host from infectious microorganisms and maintaining tissue homeostasis by clearance of altered or dying cells [ 1 ]. A growing body of evidence indicates...

... in young children. The complement system plays a crucial role in humoral immunity, complementing the ability of antibodies to clear microbes, thereby protecting the host against bacterial infections, including S. pneumoniae and N. meningitidis . While it is widely accepted that complement deficiencies due...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2017 <italic>Candida albicans</italic> Complement system...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Complement system Innate immunity Streptococcus Virulence factors Cathelicidin Antimicrobial peptides National Institutes of Health (NIH) 10.13039/100000002...

..., instructions or products referred to in the content or advertisements. 2009 Complement system Infectious diseases Innate immunity Lectins Lung Mannose-binding lectin Pneumococcus Pneumonia Sepsis Journal of Innate Immunity Review J Innate Immun 2010;2:114 122 DOI: 10.1159/000228159 Received...

...Thomas Wittenborn; Steffen Thiel; Lisbeth Jensen; Hans J. Nielsen; Jens C. Jensenius The three human ficolins, H-ficolin, L-ficolin and M-ficolin, are pattern recognition molecules of the innate immune system. All three ficolins can activate the lectin pathway of the complement system after binding...