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Keywords: Complement
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J Innate Immun (2018) 11 (1): 3–12.
Published Online: 28 September 2018
...Maisem Laabei; David Ermert The human host has evolved elaborate protection mechanisms to prevent infection from the billions of microorganisms to which it host is exposed and is home. One of these systems, complement, is an evolutionary ancient arm of innate immunity essential for combatting...
Journal Articles
J Innate Immun (2018) 10 (5-6): 455–464.
Published Online: 27 August 2018
...Dani A.C. Heesterbeek; Mathieu L. Angelier; Richard A. Harrison; Suzan H.M. Rooijakkers Complement is a complex protein network of plasma, and an integral part of the innate immune system. Complement activation results in the rapid clearance of bacteria by immune cells, and direct bacterial killing...
Journal Articles
J Innate Immun (2017) 9 (2): 217–228.
Published Online: 10 January 2017
... studies have shown that CL-K1 binds to microbes and activates the lectin complement pathway. However, in vivo functions of CL-K1 against microbes have not been elucidated. To investigate the biological functions of CL-K1, we generated CL-K1 knockout (CL-K1 -/- ) mice and then performed a Streptococcus...
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J Innate Immun (2015) 7 (4): 333–339.
Published Online: 06 February 2015
...Scott R. Barnum Activation of complement leads to generation of the 3 anaphylatoxins C3a, C4a, and C5a. Although all 3 peptides are structurally similar, only C3a and C5a share a similar functional profile that includes the classic inflammatory activities and, more recently, developmental homing...
Journal Articles
Journal Articles
J Innate Immun (2014) 6 (4): 417–425.
Published Online: 20 December 2013
...Joseph O'Flynn; Karen O. Dixon; Maria C. Faber Krol; Mohamed R. Daha; Cees van Kooten Neutrophils and complement are key members of innate immunity. The alternative pathway (AP) of complement consists of C3, factor B, factor D and properdin, which amplifies AP activation. AP has been implicated...
Journal Articles
Journal Articles
J Innate Immun (2014) 6 (1): 31–46.
Published Online: 03 July 2013
...-resistant strains. New treatment strategies are urgently needed, which requires an understanding of disease causation mechanisms. Complement is one of the first lines of defense against bacterial pathogens, and S. aureus expresses several specific complement inhibitors. The effect of extracellular proteases...
Journal Articles
Journal Articles
J Innate Immun (2012) 4 (3): 301–311.
Published Online: 16 April 2012
... specific elements of the host innate immune system, but their role in bacterial pathogenicity is unknown. For instance, the extracellular complement-binding protein (Ecb) impairs complement activation by binding to the C3d domain of C3. Its homolog, the extracellular fibrinogen-binding protein (Efb...
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Journal Articles
Journal Articles
Journal Articles
J Innate Immun (2010) 2 (5): 422–430.
Published Online: 08 June 2010
... and fibrinolysis are almost universally present in septic patients with SIRS. Increasing evidence points to an extensive cross-talk between inflammation and coagulation, in which the protease-activated cell receptors play an important role. Sepsis causes excessive activation of the complement system in which C5a...
Journal Articles
J Innate Immun (2009) 2 (1): 3–16.
Published Online: 24 September 2009
... system and function as recognition molecules in the complement system. The 3 human ficolins, ficolin-1 (M-ficolin), ficolin-2 (L-ficolin) and ficolin-3 (H-ficolin or Hakata antigen) are encoded by the FCN1 , FCN2 and FCN3 genes, respectively. Phylogenetic studies suggest that ficolins are of ancient...