...Mandy Menzel; Hamid Akbarshahi; Irma Mahmutovic Persson; Cecilia Andersson; Manoj Puthia; Lena Uller Asthma exacerbations are commonly triggered by rhinovirus infections. Viruses can activate the NFκB pathway resulting in airway inflammation and increased Th2 cytokine expression. NFκB signaling...

... oxygen species for anti-microbial effects. Conversely, anti-inflammatory macrophages use primarily FAO and oxidative phosphorylation to ensure efficient energy production and redox balance required for prolonged survival. Deregulation of metabolic reprogramming in lung diseases, such as asthma...

... ILC2 Plasticity Asthma Allergy Lung Innate lymphoid cells (ILCs) represent a relatively new family of lymphocytes that concentrate at barrier surfaces such as the skin, intestine, and lungs [ 1, 2 ]. Here, ILCs regulate tissue homeostasis by rapidly generating tailored responses...

.... However, the exact mechanisms of susceptibility are likely to differ amongst viruses. Therefore, we infected primary nasal epithelial cells (NECs) from adults with mild-to-moderate asthma, with respiratory syncytial virus (RSV) or human metapneumovirus (hMPV) in vitro and investigated the antiviral...

... to in the content or advertisements. Crohn’s disease Cancer Interleukin-17 Rheumatoid arthritis Th17 cells Ulcerative colitis Asthma The realization that single cytokines may constitute important targets for novel therapies has driven academic and industrial researchers to identify...

...J. Daan de Boer; Jack Yang; Florry E. van den Boogaard; Arie J. Hoogendijk; Regina de Beer; Jaring S. van der Zee; Joris J.T.H. Roelofs; Cornelis van 't Veer; Alex F. de Vos; Tom van der Poll Background: Mast cells are implicated in allergic and innate immune responses in asthma, although...

... in allergic asthma. We studied the effects of in vitro GT supplementation on receptor-mediated phagocytosis and expression of cell surface molecules associated with innate and adaptive immunity on sputum-derived macrophages. Cells from nonsmoking healthy (n = 6) and mild house dust mite-sensitive allergic...

... T cells through inhibition of the T helper 2 cell (Th2) responses. IFN-λs have varying immunomodulatory functions under different physiological conditions or in different organs and can inhibit tumor growth via regulation of the immune system. Diseases associated with IFN-λs include asthma, allergy...

... activated macrophage (AAM), also known as the M2 type of macrophage, in regulating allergic lung inflammation and asthma. Recent studies using mouse models of allergic lung inflammation and samples from human asthma patients contribute to the emerging concept that AAMs are not just bystanders...

...Praveen Akuthota; Jason J. Xenakis; Peter F. Weller Eosinophils have long been noted to be present in asthma and other forms of pulmonary inflammation, but whether they act as true offenders or merely as bystanders has been a point of uncertainty. However, in recent years, there has been increasing...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Allergy Asthma House dust extract Hygiene hypothesis Toll-like receptor Lipopolysaccharide tolerance National Institutes of Health (NIH) 10.13039/100000002...

... Cnidaria Nucleotide-binding and oligomerization domain-like receptor Toll-like receptor Crohn disease Asthma Journal of Innate Immunity Review J Innate Immun 2009;1:291 300 DOI: 10.1159/000211193 Received: December 17, 2008 Accepted after revision: December 20, 2008 Published online: April 2, 2009...