Abstract
Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation in vivo.
References
1.
Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L: Neutrophils: molecules, functions and pathophysiological aspects. Lab Invest 2000;80:617-653.
2.
Borregaard N: Neutrophils, from marrow to microbes. Immunity 2010;33:657-670.
3.
Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A: A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 1997;386:181-186.
4.
Adams S, van der Laan LJ, Vernon-Wilson E, Renardel DL, Dopp EA, Dijkstra CD, Simmons DL, van den Berg TK: Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol 1998;161:1853-1859.
5.
Seiffert M, Cant C, Chen Z, Rappold I, Brugger W, Kanz L, Brown EJ, Ullrich A, Bühring H-J: Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD47. Blood 1999;94:3633-3643.
6.
Oshima K, Ruhul Amin AR, Suzuki A, Hamaguchi M, Matsuda S: SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett 2002;519:1-7.
7.
Gardai SJ, Xiao YQ, Dickinson M, Nick JA, Voelker DR, Greene KE, Henson PM: By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003;115:13-23.
8.
Oldenborg P-A: CD47: a cell surface glycoprotein which regulates multiple functions of hematopoietic cells in health and disease. ISRN Hematol 2013;2013:614619.
9.
Liu Y, Bühring H-J, Zen K, Burst SL, Schnell FJ, Williams IR, Parkos CA: Signal regulatory protein (SIRPα), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem 2002;277:10028-10036.
10.
Liu Y, O'Connor MB, Mandell KJ, Zen K, Ullrich A, Buhring HJ, Parkos CA: Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha. J Immunol 2004;172:2578-2585.
11.
Liu Y, Soto I, Tong Q, Chin A, Buhring HJ, Wu T, Zen K, Parkos CA: SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J Biol Chem 2005;280:36132-36140.
12.
Latour S, Tanaka H, Demeure C, Mateo V, Rubio M, Brown EJ, Maliszewski C, Lindberg FP, Oldenborg A, Ullrich A, Delespesse G, Sarfati M: Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J Immunol 2001;167:2547-2554.
13.
Stenberg Å, Sehlin J, Oldenborg PA: Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRPα) from the cell surface. J Leukoc Biol 2013;93:403-412.
14.
Oldenborg P-A, Sehlin J: Hyperglycemia in vitro attenuates insulin-stimulated chemokinesis in normal human neutrophils. Role of protein kinase C activation. J Leuk Biol 1999;65:635-640.
15.
Böyum A: Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 1968;21:77-89.
16.
Christenson K, Björkman L, Karlsson J, Sundqvist M, Movitz C, Speert DP, Dahlgren C, Bylund J: In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation. J Leukoc Biol 2011;90:1055-1063.
17.
Follin P: Skin chamber technique for study of in vivo exudated human neutrophils. J Immunol Methods 1999;232:55-65.
18.
Borregaard N, Heiple JM, Simons ER, Clark RA: Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation. J Cell Biol 1983;97:52-61.
19.
Udby L, Borregaard N: Subcellular fractionation of human neutrophils and analysis of subcellular markers. Methods Mol Biol 2007;412:35-56.
20.
Dahlgren C, Carlsson SR, Karlsson A, Lundqvist H, Sjölin C: The lysosomal membrane glycoproteins Lamp-1 and Lamp-2 are present in mobilizable organelles, but are absent from the azurophil granules of human neutrophils. Biochem J 1995;311:667-674.
21.
Feuk-Lagerstedt E, Samuelsson M, Mosgoeller W, Movitz C, Rosqvist A, Bergström J, Larsson T, Steiner M, Prohaska R, Karlsson A: The presence of stomatin in detergent-insoluble domains of neutrophil granule membranes. J Leuk Biol 2002;72:970-977.
22.
Karlsson A, Follin P, Leffler H, Dahlgren C: Galectin-3 activates the NADPH-oxidase in exudated but not peripheral blood neutrophils. Blood 1998;91:3430-3438.
23.
Inagaki K, Yamao T, Noguchi T, Matozaki T, Fukanaga K, Takada T, Hosooka T, Akira S, Kasuga M: SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. EMBO J 2000;19:6721-6731.
24.
Okazawa H, Motegi S, Ohyama N, Ohnishi H, Tomizawa T, Kaneko Y, Oldenborg P-A, Ishikawa O, Matozaki T: Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. J Immunol 2005;174:2004-2011.
25.
Lowell CA, Fumagalli L, Berton G: Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol 1996;133:895-910.
26.
Itou T, Collins LV, Thorén FB, Dahlgren C, Karlsson A: Changes in activation states of murine polymorphonuclear leukocytes (PMN) during inflammation: a comparison of bone marrow and peritoneal exudate PMN. Clin Vaccine Immunol 2006;13:575-583.
27.
Faurschou M, Borregaard N: Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 2003;5:1317-1327.
28.
Karlsson A: Wheat germ agglutinin induces NADPH-oxidase activity in human neutrophils by interaction with mobilizable receptors. Infect Immun 1999;67:3461-3468.
29.
Mocsai A, Jakus Z, Vantus T, Berton G, Lowell CA, Ligeti E: Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. J Immunol 2000;164:4321-4331.
30.
Olsson M, Oldenborg P-A: CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcγ receptor-mediated but not scavenger receptor-mediated recognition by macrophages. Blood 2008;112:4259-4267.
31.
Martin WJ, Walton M, Harper J: Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum 2009;60:281-289.
32.
Mercer-Jones MA, Shrotri MS, Heinzelmann M, Peyton JC, Cheadle WG: Regulation of early peritoneal neutrophil migration by macrophage inflammatory protein-2 and mast cells in experimental peritonitis. J Leukoc Biol 1999;65:249-255.
33.
Zen K, Guo Y, Bian Z, Lv Z, Zhu D, Ohnishi H, Matozaki T, Liu Y: Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state. Nat Commun 2013;4:2436.
34.
Jiang P, Lagenaur CF, Narayanan V: Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 1999;274:559-562.
35.
Reinhold MI, Lindberg FP, Plas D, Reynolds S, Peters MG, Brown EJ: In vivo expression of alternatively spliced forms of integrin-associated protein (CD47). J Cell Sci 1995;108:3419-3425.
© 2014 S. Karger AG, Basel
2014
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