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Keywords: Transcription
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Journal of Biomedical Science (1996) 3 (6): 415–421.
Published Online: 11 August 2017
... of Simian Immunodeficiency Virus in C8166 Cells Can Be Overcome by Duplication of the NF-kB Binding Site Key Words Lentivirus Electrophorectic mobility shift assay Transcription ELISA AIDS Abstract Sequence analysis of the acutely lethal pbjl4 strain of simian immunodeficiency virus (SIVpbj 14) clone...
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Journal of Biomedical Science (1996) 3 (1): 20–30.
Published Online: 11 August 2017
.... The mechanism of this activation is also unclear, although there is accumulating evidence in favor of both a cytoplasmic effect involving signal transduction pathways, and a nuclear effect directly on the transcriptional machinery. lt appears that the X protein is at least as complex as many of the other...
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Journal of Biomedical Science (1996) 3 (1): 31–40.
Published Online: 11 August 2017
... a single TAR sequence. Among the two transcription initiation sites found in the HIV-1 (GER)/LTR, only the most 5' start site was shown tobe functionally active. The predictcd secondary structure of the 5'-end mRNAs of HIV-1(GER) suggests it may fold into a double TAR hairpin which resernbles that of HIV-2...
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Journal of Biomedical Science (1996) 3 (5): 323–331.
Published Online: 11 August 2017
...Jun Xu; Leo Luznik; Flossie Wong-Staal; Gordon N. Gill Both host cell and viral transcription factors regulate the long terminal repeat(LTR) of human immuno-deficiency virus (HIV) activity and viral replication. Using transient transfection, ligand-activated thyroid hormone and 9-m-retinoic acid...
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Journal of Biomedical Science (1996) 3 (3): 143–158.
Published Online: 11 August 2017
... cellular matrix, e.g. collagen and laminin, as well as cellu­ lar adhesion molecules including integrins and fibronec­ tin in certain cell lines [32, 73, 75], Many of these TGF-ß effects represent transcriptionally regulated responses me­ diated via identified promoter response elements. TGF-ß Receptors J...
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Journal of Biomedical Science (1995) 2 (2): 136–145.
Published Online: 11 August 2017
... to contain 12.5 mM MgCb and 2 mM dithiothreitol. Nuclear extracts prepared by two other meth­ ods [20, 59] also gave extracts that supported a tat response, but we transcription from the HIV-1 LTR. failed to produce transcriptionally active whole cell extracts by the To examine the role of tat and TAR...
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Journal of Biomedical Science (1995) 2 (2): 77–89.
Published Online: 11 August 2017
... Thyroid hormones Nuclear receptors Transcription Gene regulation DNA binding protein Introduction The importance of the thyroid gland in body functions was recognized as early as 1827 [84], In the late 19th cen­ tury, it was found that thyroidectomy led to myxedema which was relieved...
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Journal of Biomedical Science (1997) 4 (6): 269–278.
Published Online: 11 August 2017
...-helix leucine zipper transcription factor that acts as a heterodimer with its partner protein, Max, to activate genes regulating the cell cycle machinery as well as critical metabolic enzymes. The additional ability of c-Myc to repress transcription of differentiationrelated genes suggest that c-Myc...
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Journal of Biomedical Science (1996) 3 (6): 365–378.
Published Online: 11 August 2017
... integration of proviruses into transcriptionally active regions in DNA [96, 117]. Although the provirus has all necessary elements to function as an independent transcriptional unit, it is under major influence also from the site of integration. It has been found that identical proviruses inserted at differ­...
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Journal of Biomedical Science (2004) 11 (6): 886–901.
Published Online: 01 December 2004
...Wen-Kwei Chen; Nan-Chi A. Chang; Yen-Hwa Chang; Kuo-Long Chang; Shinn-Chih Wu; Tzong-Shang Yang; Sheue-Mei Wu; Alice Chien Chang The 5′ flanking sequence (3,227 base pairs, bp) of the mouse Adra2c subtype gene was determined and characterized. The transcription start site was mapped to nucleotide...
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Journal of Biomedical Science (2000) 7 (2): 144–151.
Published Online: 31 March 2000
... pathway, because reporter genes downstream of the Sp1-binding sites were not activated in a PKA-deficient cell line. Transfection of the catalytic subunit of PKA restored activated transcription. Similar Sp1-binding sites identified in the CYP11A1 and CYP21 genes also controlled cAMP-dependent...
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Journal of Biomedical Science (1999) 6 (3): 206–212.
Published Online: 12 May 1999
... Transcription W Genetics 77 mutant demonstrated that it is not the site of phosphorylation. These studies demonstrate the importance of using relevant cell lines to characterize the role of phosphorylation in protein function. Abstract The human T cell leukemia virus type 1 (HTLV-1) Tax is a phosphoprotein...
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Journal of Biomedical Science (1998) 5 (3): 211–220.
Published Online: 02 July 1998
... cells and it should be taken into account when considering the mode of action of HIV-1 Tat in a particular system at a defined stage. Unlike the mouse embryo, for which zygotic transcription starts at the 2-cell stage [50], the Xenopus embryo is transcriptionally quiescent until the mid-blastula...
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Journal of Biomedical Science (1998) 5 (1): 24–27.
Published Online: 18 March 1998
...Kuan-Teh Jeang The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat...