... the central roles of these signaling cascades. Interestingly, CCY1a also effectively blocked serum-induced IĸB-α phosphorylation, IĸB-α degradation and nuclear factor-ĸB (NF-ĸB) binding activity. Based on these observations, we examined the effect of CCY1a on serum-mediated Ras activity, an upstream regulator...

...) proteins. Many cellular effects elicited by v-Src are mediated through Ras, a molecular switch linking growth factor receptors and non-receptor tyrosine kinases to many downstream effectors. In this report, we demonstrated that v-H-Ras and v-Src both induced cellular transformation. However, the activation...