...Chih-Chia Lai; Mei-Chi Chang; Hsun Hsun Lin The present study was performed to examine the effects of acute ethanol exposure on N-methyl- D -aspartate (NMDA)-induced responses and the development of acute tolerance in rat rostral ventrolateral medulla (RVLM) in vivo and in vitro. Repeated...

...Song-Chow Lin; Chia-Hsien Lin; Chun-Ching Lin; Yun-Ho Lin; Chin-Fa Chen; I-Cheng Chen; Li-Ya Wang Arctium lappa Linne (burdock) is a perennial herb which is popularly cultivated as a vegetable. In order to evaluate its hepatoprotective effects, a group of rats (n = 10) was fed a liquid ethanol diet...

...Grzegorz A. Czapski; Grace Y. Sun; Joanna B. Strosznajder The ionotropic glutamatergic receptor system, especially the subtype mediated by N-methyl- D -aspartic acid (NMDA), is known to exhibit special sensitivity to the effect of ethanol. This is due partly to the ability of ethanol to modulate...

...W. Gibson Wood; Nicolai A. Avdulov; Svetlana V. Chochina; Urule Igbavboa Ethanol has a pronounced effect on lipid homeostasis. It is our overall hypothesis that certain lipid carrier proteins are targets of acute and chronic ethanol exposure and that perturbation of these proteins induces lipid...

...Albert Y. Sun; Grace Y. Sun There is strong evidence showing that chronic and excessive ethanol consumption may enhance oxidative damage to neurons and result in cell death. Although not yet well understood, ethanol may enhance ROS production in brain through a number of pathways including...

...Jing-Hung Wang; Grace Y. Sun Chronic and excessive ethanol consumption is known to alter neuron and glial cell functions in the central nervous system (CNS). Astrocytes comprise the major cell type in the brain. These immune active cells are capable of responding to proinflammatory cytokines...

...Roberta M. Magai; Shivendra D. Shukla The metabolic fate of ethanol into the phospholipid pool of calf pulmonary artery endothelial cells was studied. [ 14 C]-ethanol was incorporated into various endothelial cell phospholipids including phosphatidylethanol (PEth), which may represent a substantial...

...Tomáš Zima; Lenka Fialová; Oto Mestek; Marta Janebová; Jiřina Crkovská; Ivan Malbohan; Stanislav Štípek; Ludmila Mikulíková; Petr Popov Alcohol-induced oxidative stress is linked to the metabolism of ethanol. Three metabolic pathways of ethanol have been described in the human body so far...

.... This study analyzed basal and ethanol-induced cardiac contractile response using left-ventricular papillary muscles and myocytes from lean and obese Zucker rats. Contractile properties analyzed include: peak tension development (PTD), peak shortening amplitude (PS), time to PTD/PS (TPT/TPS), time to 90...

... hydrolysis of arachidonic acid from membrane phospholipids. Following exposure of macrophages to various foreign or endogenous stimulants, cytosolic phospholipase A 2 is activated. Treatment with these compounds may also stimulate phospholipase D activity, and, in the presence of ethanol, phospholipase D...

...Chung-Eun Ha; Charles E. Petersen; David S. Park; Krishna Harohalli; Nadhipuram V. Bhagavan Ethanol effects on warfarin binding to human serum albumin (HSA) have been studied by equilibrium dialysis and fluorescence methods at pH 7.4 in phosphate-buffered saline at 37°C. In the presence of various...

...Guochuan Tsai Substance abuse and dependence is the most common psychiatric problem. Alcohol is the most commonly abused substance and most people who abuse other substance(s) abuse alcohol at the same time. Accumulating evidence suggests that neurophysiological and pathological effects of ethanol...