...Sue Lin-Chao; Chuck C.K. Chao The influence of cisplatin, an anticancer agent, on DNA synthesis and cell cycle progression of a cisplatin-resistant cell line was investigated. Cell cycle analysis using flow cytometry showed that cytotoxic concentrations of cisplatin caused a transient inhibition...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Apoptosis Cell cycle 3-Deazaadenosine analogs L1210 lymphocytic leukemia cells...

... caused a potent antiproliferative effect resulting from the downregulation of the key cell cycle regulators, the cyclin-dependent kinases (CDKs). CDK activity was lost due to a twofold effect, the increased expression of the CDK inhibitors p21 Cip1 and p27 Kip1 in combination with the reduced expression...

... Senescence Zee-Fen Chang Duen-Yi Huang Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC Key Words Senescence W Thymidine kinase W Cell cycle Abstract As human diploid fibroblasts (HDFs) in culture senesce, the expression of thymidine kinase (TK) and the activity...

...Shun-Chun Yang; Chian-Hoang Huang; Nien-Jung Chen; Cheng-Kung Chou; Chi-Hung Lin Protein phosphorylation is involved in many biological activities and plays important roles in cell cycle progression. In the present study, we identified a serine/threonine kinase, hAIK, from human hepatic cells using...

... of the process of apoptosis. In addition, our results also suggest that p53 gene status modulates the extent of chemosensitivity and the induction of apoptosis by different anticancer agents in NSCLC cells. 13 1 2000 p53 Chemosensitivity Cell cycle Apoptosis Non-small cell lung cancer...