...I.K. Kim; R.L. Copeland; J.H. Lee; H.S. Kim; E. Asafo-Adjei; N.D. Brown; J.S. Estrada; R.K. Gordon; G.E. Garcia; P.K. Chiang High concentrations of adenosine (Ado), when added to L1210 lymphocytic leukemia cells, resulted in apoptosis or programmed cell death. The apoptotic process was accompanied...

...Atsuko Ishizuya-Okav; Yun-Bo Shi The thyroid hormone (T(3))-dependent amphibian metamorphosis involves degeneration of larval tissues through programmed cell death ( apoptosis) and concurrent proliferation and differentiation of adult cell types. As the mediators of the causative effects of T(3...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. c-Myc Oncogene Transcription Cancer Metabolism Apoptosis Journal cf Biomedicai Science Review J Biomed Sci 1997;4...

...In-Kyng Kim; Chou-Chi H. Li; Howard A. Young; Jeong-Hwa Lee; Ho-Shik Kim; K. Pardhmaradhi; Gregory E. Garcia; Peter K. Chiang A new class of potent apogens (apoptosis-inducing agents) has been identified,consisting of 3-deazaadenosine (DZA), 3-deaza-( ± )aristeromycin (DZAri)and l-ß-D...

... in MCF-7 human mammary carcinoma cells. Plant extracts of A. formosanus were observed to induce apoptosis of MCF-7 cells as evidenced by cell-morphological changes, an early redistribution of plasma membrane phosphatidylserine, and DNA content distribution studies. Bioactivity-guided fractionation...

... on thioacetamide (TAA)-induced hepatotoxicity in mice. We found that MDL28170 significantly decreased mortality and change in serum transaminase after TAA administration. The necroinflammatory response in the liver was also suppressed. Furthermore, a significant suppression of hepatocyte apoptosis could be found...

... to in the content or advertisements. Oxygen-glucose deprivation Hypoxia/reoxygenation Nicotinamide Apoptosis Caspase-3 Reactive oxygen species c -fos Original Paper J Biomed Sci 2004;11:472 481 DOI: 10.1159/000077897 Received: November 11, 2003 Accepted: February 3, 2004 Protective Effect...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. A1 Reactive oxygen intermediate Neutrophils HL-60 cells Apoptosis Cell death Original Paper J Biomed Sci 2004;11:214 227 DOI: 10.1159/000076034 Received: June 25...

... to release histotoxic granular contents. Since numerous cellular proteins are degraded during apoptosis, we sought to determine whether functional serine proteinases are indeed released by apoptosing neutrophils in vitro. In a coculture system, cytokine-activated neutrophils induced detachment in the human...

... (dPC12) were used to study the role of ROS in cell death induced by Aβ 25–35 . The viability of PC12 and dPC12 cells decreased by 30–40% after a 48-hour exposure to 20 µ M Aβ 25–35 . Microscopic examination showed that Aβ 25–35 induced necrosis in PC12 cells and apoptosis in dPC12 cells. Vitamin E (100 µ...

..., not only induces RARγ-dependent differentiation, but in contrast to RA, it also induces RARγ-independent apoptosis in many tumor cells. This observation makes this and similar new retinoids very interesting from a clinical perspective. Several genes have been associated with CD437/AHPN-mediated apoptosis...

... from apoptosis. Using an intracellular reactive oxygen species (ROS) fluorescent dye, 2′,7′-dichlorofluorescin diacetate, heterogeneous distribution of ROS inside astrocytes was observed after laser irradiation. The level of ROS in the mitochondrial compartment was found to be higher than in other...

...Maria L.R. Lim; May-Ghee Lum; Tania M. Hansen; Xavier Roucou; Phillip Nagley Mitochondria play key roles in apoptosis, a central step being the release of cytochrome c (cyt c) across the outer mitochondrial membrane into the cytoplasm. We review this process in terms of the influences that induce...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mitochondria Mitochondrial DNA Apoptosis Autophagy Reactive oxygen...

... as a reservoir for viral replication in the host. Although macrophages are generally resistant to apoptosis, interruption of anti-apoptotic pathways can render them susceptible to apoptosis. Here we report that HIV-1 BAL infection of primary human monocyte-derived macrophages (MDM) upregulates the mRNA...

... cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to cisplatin/nifedipine treatment. Both cell lines demonstrated an apoptotic response by more than one criterion. Apoptosis was demonstrated by DNA fragmentation techniques such as DNA laddering, ApopTag ®...

...Mingjie Zhang; Xingxiang Li; Xiaowu Pang; Linna Ding; Owen Wood; Kathlene Clouse; Indira Hewlett; Andrew I. Dayton The induction of apoptosis in T cells by bystander cells has been repeatedly implicated as a mechanism contributing to the T cell depletion seen in HIV infection. It has been shown...

...Samuel W. French The intragastric alcohol infusion rat model (IAIRM) of alcoholic liver disease (ALD) has been utilized in various laboratories to study various aspects of ALD pathogenesis including oxidative stress, cytokine upregulation, hypoxic damage, apoptosis, ubiquitin-proteasome pathway...

...Jeff W. Chen; Julian Lin; N. Madamanchi; Todd T. Trier; Gerald Campbell Apoptosis has been implicated recently as a prominent response of the brain to a variety of insults, such as ischemia and trauma. In this study, we demonstrate that apoptosis is a prominent part of the brain’s response...

...Lung-Ji Chang; Chih-Hsiung Chen; Vicki Urlacher; Tze-Fun Lee The growth inhibitory effects of Vpr and Vpx are species- and cell type-dependent. HIV-1, HIV-2 and SIV Vpr are primarily cytostatic in mammalian cells and HIV-1 Vpr has been reported to induce apoptosis in human cells. Our previous...