Less than 5% of people infectcd with human T-lymphotropic virus type I(HTLV-I) develop HTLV-I-associated myelopathy/tropical spastic paraparesis(HAM/TSP), a chronic progressive neurologic disease. A number offactors have bcen implicated in the development ofHAM/TSP including heterogeneity of viral sequences, host-genctic background, viral-specific cellular immune responses and viral load. This study examined the presence of HTLV-1 tax DNA in peripheral blood lymphocytes (PBL) from 2 chronic HAM/TSP patients and 2 asymptomatic HTLV-I carriers by using PCR-in situ hybridization(PCR-ISH) for the in situ presence ofproviral HTLV-I tax DNA. By this technique, rare PBL from thesc HTLV-I-infected individuals contained HTLV-1 DNA. PCR-ISH did not detect any difference in the number of infected cells between HAM/TSP patients and asymptomatic carriers.

Keywords:
HTL V- I infection, HTLV-1-associated myclopathy/tropical spastic paraparesis, PCR-in situ hybridization
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1997
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