Abstract
The Rev axis of HIV autoregulation is one of two critical viral regulatory pathways required for exprcssion of viral genomic and mRNA and for replication. Conscqucntly it is an attractivc therapeutic target. Previous studies havc invcstigatcd the anti-HIV efficacy of targeting to the RRE (the viral RNA targct scquence ofthe Rev axis) a trans-dominant negative inhibitor mutant Rcv, M 10. In this study we have fused a portion ofthc influenza virus NS1 protein(which normally inhibits polyA(+) mRNA transport and splicing) to the Rev M 10 gene while deleting th1 NS1 poly(A) binding region. The resulting chimera demonstrates specific and enhanced inhibition of viral-RRE-containing RNA expression.
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1997
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