...D.F. Smith The effects of lithium on spontaneous activity, exploratory activity, hyperactivity and stereotypy induced by drugs, drug-induced hypoactivity and activity rhythms of animals are reviewed. Attention is given to the rationale for the studies and the relation of research on motor activity...

...R. Yassa; J. Ananth In this paper, the efficacy of lithium therapy in the treatment of tardive dyskinesia is reviewed. It is noted that most of the published papers on this topic are anecdotal and single case reports with contradictory results. The well-designed studies indicate that lithium...

...Jean-Louis Imbs; Léonard Singer; Jean-Marie Danion; Mariette Schmidt; Richard Zawilslak Wistar rats were given lithium chloride (16.7 mg/kg i.p.) after treatment with indomethacin (2.5 mg/kg/day for 5 days), with methylprednisolone (3 mg/kg/day for 5 days), or with their solvents. Lithium...

...M. Ragheb The interaction of neuroleptics, tricyclic antidepressants, monoamine oxidase inhibitors, lithium and anxiolytic sedatives with other drugs and food is reviewed with special emphasis on drug interactions commonly encountered in psychiatric practice. Clinical relevance and mechanism...

...Charles L. Bowden; John P. Houston; Robert S. Shulman; Jaquelyn M. Clothier Saliva, plasma and erythrocyte lithium concentrations were studied in 40 long-term lithium users. Intersubject variation in saliva to plasma lithium ratio was too great for clinical utility, when based on a group linear...

...A. Preston West A large variability in the rates of lithium-induced toxic-confusional states is noted in studies of lithium treatment of schizophrenic and schizoaffective patients. Treatment and subject factors which might contribute to this variability are reviewed. A greater frequency of lithium...

...F. Okada; M. Honma; M. Ui We have measured the rise in plasma cyclic AMP induced by glucagon and adrenaline in manic patients on lithium therapy. Glucagon-induced increases in the concentration of plasma cyclic AMP were larger, but the adrenaline-induced increases were smaller, in lithium-treated...

...Takashi Ebara; Kazuo Nakayama; Saburo Otsuki; Shosuke Watanabe Orthodromic and antidromic conduction velocities were measured in the tail nerve of rats given lithium throughout life. Lithium at nontoxic levels failed to influence nerve conduction velocities. Lithium at toxic levels (2 X 2.5 mmol/kg...

...B. Lerer; R.P. Ebstein; A. Felix; R.H. Beimaker Oral lithium pretreatment of rats for 19 days significantly prevented the behavioral immobility induced by moderate doses of reserpine. High doses of reserpine overwhelmed the lithium effect. Development of a simple and specific behavioral test...

...L. von Knorring; L. Smigan; C. Perris; L Oreland The lithium RBC/plasma ratio was determined in 59 patients during prophylactic lithium therapy. No relationship was found between the lithium RBC/plasma ratio and sex, age, type of illness, weight, lithium dosage, duration of treatment or lithium...

..., administered intraperitoneally to the rats, was increased in brain glucose and brain lactate, and decreased in brain glutamate. The results were explained by a lithium-induced increase in brain glucose uptake and an increased rate of glycolysis,and a slight inhibition of the oxidative decarboxylation...

...W. Girke; F.-A. Krebs; B. Müller-Oerlinghausen (1) EMG investigations in 17 female manic-depressive patients under longterm treatment with lithium salts showed a reduction of the maximal motor nerve conduction velocity (NCV) and of the duration of isolated potentials (IPs) in six cases...

...S. Bellwinkel; A. Schäfer; A. Schäfer; H. Minne; R. Ziegler Rats were treated with lithium chloride over 6 weeks. During the experiment,determinations of serum calcium, magnesium and phosphorus revealed no changes due to the therapy. Postmortem examinations of liver, skeletal muscle, and femur...

...John R. Samples; Marjorie E. Seybold The effects of lithium on the tail nerve conduction velocity of the rat were studied. No effect of lithium on the conduction velocity was found, even at toxic serum lithium levels. No effect of lithium on repetitive stimulation of the distal forelimb flexor...

...A. Kierkegaard-Hansen; E.B. Pedersen; S. Darling; A. Amdisen Plasma renin activity (PRA) was determined in patients given lithium treatment. In a longitudinal study PRA was determined in 9 patients before the start of lithium treatment and at intervals during 3 months of treatment. The activity...

...Erling T. Mellerup; Per Plenge Rats were treated with lithium chloride for 8 weeks. At the last day of lithium administration, the animals were given radioactive calcium, magnesium, and phosphate. Electrolyte content and radioactivity were determined in serum, bone, muscle, liver and brain. Lithium...

...U. Bonetti; F. Johansson; L. von Knorring; C. Perris; E. Strandman 61 patients - 28 suffering from bipolar, and 33 from unipolar psychotic affective disorders - completed two personality inventories, one before and one about 6 months after starting lithium treatment to prevent relapses...

...E.B. Pedersen; S. Darling; A. Amdisen; A. Kierkegaard-Hansen Inspired from experiments in animals, plasma renin substrate was determined in patients given lithium treatment. In a longitudinal study, renin substrate was determined in 9 patients before the start of lithium treatment and at intervals...

...Muneo Shimizu; Donald F. Smith Samples of saliva were collected from healthy subjects given a test dose of lithium carbonate. Lithium clearance in saliva was well related to salivary potassium clearance but not to salivary sodium clearance. Stimulation of adrenocortical activity by changing from...

...Klaus Opitz; Genoveva Schäfer The influence of lithium on ingestive behavior and body weight was studied in male and female rats. Single i.p. doses of LiCl (3.6-7.2 mmol/kg) reduced both food intake and water consumption. Repeated large doses of LiCl given intraperitoneally caused a prompt anorexia...