A longitudinal investigation was conducted with respect to EEGs,following electroconvulsive shock treatment, and autonomic function as well as regarding some clinical aspects in a total of 119 schizophrenic patients. Following a system of classification based on clinico-genetic studies, two groups of schizophrenia, typical and atypical,were differentiated also at a phenogenetic level. The findings were interpreted with a view of recognizing differential cerebral pathology in two groups of schizophrenia which could be localized at the diencephalic level. The typical group appeared to be characterized by poor autonomic reactibility, more or less irreversible in nature, associated clinically with lack of affective rapport, whereas reversible autonomic lability and/or over-reactibility, associated with exaggerated affectivity appeared characteristic for the atypical group.

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