A study of 23 patients (16 females, 7 males), diagnosed as suffering from anxiety, was carried out using a flexible dosage regimen of doxepin. Hamilton Anxiety Rating Scale scores were assessed on days 0, 7, 14 and 21 and plasma doxepin and desmethyldoxepin concentrations were analysed from blood samples taken on days 7, 14 and 21 of the trial. No simple correlation between the Hamilton score at day 21 and plasma doxepin concentration (r(s) = -0.099 p > 0.05; n = 19) or plasma desmethyldoxepin concentration(r(s) = 0.339; p > 0.05; n = 19) was obtained. The sum of doxepin and desmethyldoxepin concentrations was not correlated with Hamilton score at day 21 (r(s) = 0.276 ; p > 0.05;n = 19). No correlation of doxepin, desmethyldoxepin or total concentrations and Hamilton score was found on days 7 or 14 of the trial.

Keywords:
Doxepin, Anxiety, Plasma concentration, Hamilton Anxiety Scale, Gas chromatography, Desmethyldoxepin, Clinical response
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1980
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