1. Effects of haloperidol on EEG were examined in rabbits, curarized and artificially respired. Twenty-five rabbits were used for studying the effect of acute administration and 25 rabbits for chronic administration. 2. Haloperidol in doses of 1.5—4.0 mg/kg i.v. evoked two main changes in the EEG. Namely, a synchronization of cortical and subcortical EEG patterns and a continuous desynchronized pattern in the olfactory bulb. In addition, the cortical EEG arousal reactions to clap and pain were blocked at 1.8 ± 0.8mg/kg and 2.9 ± 0.8 mg/kg respectively. Hippocampal arousal reaction to these stimulations was not completely blocked. 3. When more than 4.5 mg/kg was given, EEG activities of all the brain areas showed a continuous arousal pattern in 8 rabbits out of 15. 4. There are two chief negative results. The chronic administration of haloperidol for 2—10 days did not significantly affect the per cent time distribution of arousal, mixed and resting patterns. Moreover,threshold voltages required to induce hippocampal seizure discharges following electrical stimulation of hippocampus were not significantly raised with the acute administration of 1.5 mg/kg of haloperidol.

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1968
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