...M. Roggendorf; T.K. Tolle Since the discovery of woodchuck hepatitis virus (WHV) in 1978, the virus and its host, the American woodchuck, have been studied and used as the most suitable model for human hepatitis B virus infection. WHV is closely related to the human virus, having strong...

... recombinants which might be able to infect woodchucks by exchanging different portions of the pre-S1 encoding gene with homologous parts from the related woodchuck hepatitis virus (WHV) in a cloned HBV genome. In 6 mutants, 11–92 N-terminal HBV pre-S1 codons were replaced by 20–120 codons from WHV. Four...

... to test vaccine candidates is the woodchuck chronically infected with the woodchuck hepatitis virus (WHV); the woodchuck can be superinfected with HDV and shows a course of infection similar to that of patients. Different strategies have been investigated to establish a protective vaccine against HDV...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Woodchuck Woodchuck hepatitis virus T-cell responses Vaccination Intervirology 2001;44:124 131 Evaluation of New Approaches to Prophylactic and Therapeutic Vaccinations...