...Hyun Jung Lee; Jong Eun Yeon; Eileen L. Yoon; Sang Jun Suh; Keunhee Kang; Hae Rim Kim; Seong Hee Kang; Yang Jae Yoo; Jihye Je; Ji Hoon Kim; Yeon Seok Seo; Hyung Joon Yim; Kwan Soo Byun Objectives: Interferon (IFN)-based therapy for chronic hepatitis C (CHC) is cost-effective and is associated...

...Maurizia Rossana Brunetto; Ferruccio Bonino Chronic hepatitis B (CHB) results from the inability of the host's immune system to control viral replication. Interferon-α (IFN-α) therapy can convert CHB into inactive hepatitis B virus (HBV) infection in 20-30% of the treated patients. In spite...

... (HCV)-related compensated cirrhosis is still unclear. Methods: In study 1, in 157 consecutive patients with HCV-related compensated cirrhosis, treatment efficacy with interferon plus ribavirin therapy was evaluated for 48 weeks of HCV genotype 1b (HCV-1b) or 24 weeks of HCV-2a/2b. In study 2, in 185...

... (HCV) genotype 1b (HCV-1b) is an important predictor of hepatocellular carcinoma (HCC), but its impact on HCC in nonresponders to interferon (IFN) and ribavirin (RIB) combination therapy is not clear. Methods: A total of 292 patients with HCV-1b-related chronic liver disease who did not achieve...

... efficacy to interferon (IFN)/ribavirin in patients infected with HCV genotype 1b (HCV-1b). Methods: This study investigated pretreatment predictors, including viral- (aa substitutions in core aa 70/91 and NS5A-ISDR/IRRDR) and host-related factors (genetic variation near IL28B gene), to 48-week IFN...

... subcutaneous interferon-α (IFN-α) 6 million units (MU) daily for 7 days at week 29. He cleared HCV RNA from the serum and remained negative for it during 25 weeks after the withdrawal of IFN. The other (C-224) did not respond to 2 courses of a short-term IFN monotherapy at weeks 20 and 23. Twelve weeks...

..., instructions or products referred to in the content or advertisements. Hepatitis C virus Genotype 2 Interferon Ribavirin Combination therapy, extended Early virological response Original Paper Intervirology 2010;53:188 192 DOI: 10.1159/000289343 Received: November 2, 2009 Accepted after revision...

... Accepted after revision: November 2, 2009 Published online: January 13, 2010 Relationship between Regulatory T Cells and the Combination of Pegylated Interferon and Ribavirin for the Treatment of Chronic Hepatitis Type C Motohisa Akiyama Tatuki Ichikawa Hisamitsu Miyaaki Yasuhide Motoyoshi Shigeyuki...

... region of HCV genotype 1b is a useful pretreatment predictor of poor response to interferon + ribavirin combination therapy, but the impacts of aa substitutions in the core region of HCV genotype 2a are still not clear. Methods: 154 consecutive Japanese adults with a high viral load (≥100 kIU/ml...

... interferon (IFN)-α and ribavirin combination therapy resistance, we examined the STAT expression in the liver. Methods: We immunostained Phospho-STAT1 (P-STAT1) and Phospho-STAT3 (P-STAT3) in 59 hepatitis C virus (HCV)-infected liver tissues and compared the expression of these STATs proteins...

...Yasuji Arase; Fumitaka Suzuki; Hitomi Sezaki; Yusuke Kawamura; Yoshiyuki Suzuki; Masahiro Kobayashi; Norio Akuta; Tetsuya Hosaka; Hiromi Yatsuji; Miharu Hirakawa; Mariko Kobayashi; Kenji Ikeda; Hiromitsu Kumada Objectives: The aim of this study was to elucidate the efficacy of interferon (IFN...

...Carolina Scagnolari; Simona Trombetti; Simona Cicetti; Silvia Antonelli; Carla Selvaggi; Lorena Perrone; Michela Visca; Sara Romano; Guido Antonelli The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral...

... of combination therapy of different nucleoside analogues as well as on combination of lamivudine with interferon are also highlighted. Although lamivudine seems to be highly effective in most patients at the start of therapy, development of resistance by mutations in the viral polymerase is a significant...

... and often ineffective. They comprise cytodestructive and cytotoxic substances, surgical methods, laser and cryotherapy. Immunotherapy seems to be one of the more promising options. Interferons combined with ablative methods such as CO2 laser can prevent recurrence of disease. Cytokine enhancement is an old...

...William J. O’Brien; Kim Piotrowski; Jerry L. Taylor Interferon-α (IFN-α) combined with acyclic guanine analogs synergistically inhibits replication of herpes simplex virus type 1. IFN-α treatment influenced the metabolism of exogenously supplied nucleobases and nucleosides in a manner expected...

...Bodil Lidin; Alice Adams Two human lymphoid cell lines, Raji and Namalwa, and seven somatic cell hybrids between these two cells were tested for spontaneous interferon production. Namalwa and three of the hybrids produce interferon while the four other hybrids, like Raji, do not. Though the Namalwa...

... tissues from animals dying later. Histological changes were similar to those reported in rhesus monkeys after parenteral Junin viral infection. Gastrointestinal necrosis, however, was less severe in aerosol-infected animals and the associated septicemia was not seen. High levels of alpha interferon were...

...Reitu Agrawal; Jukka Pelkonen; Rauno A. Mäntyjärvi We have studied the effect of gamma-interferon (IFN-γ) treatment on the transcription of viral and c- myc oncogenes in bovine papillomavirus type 1 (BPV-1)-transformed mouse fibroblast cell lines. Upon IFN-γ treatment, viral transcripts always...

...Marlyn P. Langford; Ramon M. Kadi; James P. Ganley; Marguerite Yin-Murphy Natural human interferons (IFN) and recombinant human IFNs (rIFN-α and rIFN-β) inhibited the production of virus in Chang’s human conjunctival cell cultures infected with epidemic isolates of acute hemorrhagic conjunctivitis...

... and severity of the disease. Apart from providing an etiologic diagnosis, there are therapeutic implications from the in situ demonstration of myocardial enterovirus infection. Evaluation of specific antiviral agents, for example interferons, may lead to the development of new therapeutic strategies capable...