... the presentation of multiple copies of the target epitopes. Utilizing VLPs as vaccine platforms to present exogenous antigens is a promising and challenging approach in the vaccine development field. This study investigates the potential of the truncated hepatitis E virus (HEV) capsid as a VLP platform to present...

...Jiyue Wen; Weizhuo Lu; Zhenzhen Liu; Jihong Meng Aims: To confirm the different characteristics of genotype-specific and common neutralizing epitopes of hepatitis E virus (HEV). Methods: A competitive binding assay was established with known genotype-common neutralizing monoclonal antibodies (mAbs...

...Ruchi Pathak; Pradip V. Barde Background and Aims: An acute hepatitis, caused by hepatitis E virus (HEV), is a significant global health concern, especially in developing countries. HEV has 1 serotype and 8 genotypes, which are further divided into subtypes. Despite the availability of sporadic...

... of hepatitis E virus (HEV) infections with those of other acute viral hepatitis infections in Korea. Methods: This study included 2,357 consecutive patients who were diagnosed with acute hepatitis, based on acute illness with jaundice or elevated alanine aminotransferase levels (>100 IU/L), between January...

...Sven Pischke; Carolynne Schwarze-Zander; Birgit Bremer; Patrick Lehmann; Steffen B. Wiegand; Anett Gisa; Patrick Behrendt; Christian P. Strassburg; Michael P. Manns; Heiner Wedemeyer; Jürgen K. Rockstroh Objectives: Cases of chronic hepatitis E virus (HEV) infection have been described in HIV...

...Yanis Bouamra; René Gérolami; Jean-Pierre Arzouni; Jean-Charles Grimaud; Pierre Lafforgue; Marjorie Nelli; Natacha Tivoli; Audrey Ferretti; Anne Motte; Philippe Colson In Europe, autochthonous hepatitis E is caused by genotype 3 hepatitis E virus (HEV) in almost all cases. A total of 15 infections...

...Mohammad Khalid Parvez Very recently, an unusual clinical presentation with an altered natural history associated with hepatitis E virus (HEV) infection has emerged in high-income industrialized nations. Although HEV infection does not develop into chronicity in general, viremia can persist...

...Mamadou Kaba; Valérie Moal; René Gérolami; Philippe Colson Mammalian hepatitis E virus (HEV), the etiological agent of hepatitis E in humans, is a recently discovered infectious agent. It was identified for the first time in 1983 using electron microscopy on a faecal specimen of a person infected...

...Valérie Moal; René Gerolami; Philippe Colson Hepatitis E virus (HEV), the main etiologic agent of enterically transmitted acute hepatitis in developing countries, is now recognized as an emerging agent of autochthonous disease and chronic hepatitis E in immunocompromised patients in Europe where...

...Fusheng Si; Qian Yang; Yumin Zhu; Shijuan Dong; Ruisong Yu; Shiyuan Shen; Zhen Li We studied the distribution and development of hepatitis E virus (HEV) genotypes 3 and 4 in pig farms located within the Shanghai metropolitan area. A total of 1,487 swine fecal samples were collected from 39 pig...

...S. Saravanabalaji; A.S. Tripathy; R.R. Dhoot; M.S. Chadha; A.L. Kakrani; V.A. Arankalle Objectives: Hepatitis E virus (HEV) is the predominant cause of water-borne epidemics, sporadic acute viral hepatitis (AVH) in adults and fulminant hepatic failure (FHF) among pregnant women and other adults...

...Hidenori Toyoda; Takashi Honda; Kazuhiko Hayashi; Yoshiaki Katano; Hidemi Goto; Takashi Kumada; Kazuaki Takahashi; Natsumi Abe; Shunji Mishiro; Junki Takamatsu Objective: We investigated the prevalence of antibody against hepatitis E virus (HEV) in Japanese patients with hemophilia. Methods: IgG...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Hepatitis B virus Hepatitis C virus Hepatitis E virus Human immunodeficiency virus Epidemiology HBV genotypes Vaccination Indonesia Original Paper Intervirology...

...Pengcheng Xun; Feng Chen; Chen Dong; Guohua Qian; Dejian Lai; Jihong Meng In this article, a statistical score method for comparison of partial genomic regions in their representatives of full-length genome of hepatitis E virus (HEV) for genotyping was developed. The critical values...

...A. Bayram; F. Eksi; M. Mehli; E. Sözen Objectives: To investigate the prevalence of hepatitis E virus (HEV) among patients with chronic hepatitis B and chronic hepatitis C, serum samples were collected between January and December 2004 from patients with chronic hepatitis B and chronic hepatitis C...

...Masami Koike; Kazuaki Takahashi; Shunji Mishiro; Atsushi Matsui; Mie Inao; Sumiko Nagoshi; Akihiko Ohno; Satoshi Mochida; Kenji Fujiwara Although the majority of hepatitis E virus (HEV) infections in Japan are ‘domestic’ due to the presence of indigenous strains, there are still ‘imported’ cases...

...Kazuaki Takahashi; Jong-Hon Kang; Sachiyo Ohnishi; Kunihiko Hino; Hiroshi Miyakawa; Yuzo Miyakawa; Hiroshi Maekubo; Shunji Mishiro Objective: Ranges of variation and conservation in sequence need to be defined for detecting and genotyping hepatitis E virus (HEV). Methods: Six HEV isolates from...

...Minako Hijikata; Shigeki Hayashi; Ngoc Thi Trinh; Le Dang Ha; Hiroshi Ohara; Yohko K. Shimizu; Naoto Keicho; Hiroshi Yoshikura To identify the genotype of Vietnamese isolates of human hepatitis E virus (HEV), phylogenetic analysis was performed for the open reading frame (ORF) 1 and ORF2 nucleotide...

..., 1998 Accepted after revision: July 2, 1999 Hepatitis E Virus: An Update on Its Molecular, Clinical and Epidemiological Characteristics Mohammad Irshad Clinical Biochemistry Division, Department of Laboratory Medicine, AIIMS, New Delhi, India Key Words Hepatitis E virus W Hepatitis W Hepatitis...

...Patrice O. Yarbough Hepatitis E, previously known as enterically transmitted, enteric, or epidemic hepatitis, is a worldwide public health problem. The causative agent, the hepatitis E virus, is involved in epidemic, sporadic, and fulminant hepatitis cases worldwide. This review describes...