...Fan Gao; Xia Li; Xiaona Wang; Hankui Liu; Wentao Zhang; Yidan Zhang; Yanju Jia; Ziyan Zhao; Guiqin Bai Introduction: This study aimed to investigate the differences between pregnant women with chronic hepatitis B virus (HBV) infection and intrafamilial infection and those without intrafamilial...

...Peipei Pan; Jiaohui Li; Wei Lin; Guangyan Long Introduction: Hepatitis B virus (HBV) infection is a disease with high incidence and lack of effective treatment. In this study, we further explored the mechanism of resveratrol (RVT) in the inhibition of HBV replication. The effects of RVT on HBV...

... 257 million people worldwide. According to the WHO latest estimates, 2 billion people have been infected with hepatitis B virus (HBV) around the world. In 2015, 887,000 people died due to complications caused by HBV infection, notably cirrhosis and hepatocellular carcinoma [1, 2]. Prevalence...

...Ganesan Praveenkumar; Chaitali Nikam; Ragoori Venkata Ramana; Sengupta Caesar; Velumani Amruta; Ahmad Riyaj Background: Monitoring of hepatitis B virus (HBV) viral load has become an essential phase in the treatment of HBV. There are many commercial assays available for HBV viral load...

...Hua-Bing Liu; Qin-Yan Chen; Xue-Yan Wang; Lu-Juan Zhang; Li-Ping Hu; Tim J. Harrison; Chao Wang; Zhong-Liao Fang Background: Serum osteopontin (OPN) concentrations were found to be significantly increased in patients infected with hepatitis B virus (HBV) and patients with hepatocellular carcinoma...

...Alireza Mohebbi; Fahimeh Azadi; Mohammad Mostakhdem Hashemi; Fatemeh Sana Askari; Nazanin Razzaghi Background: Many efforts are currently focused on functional treatment of the hepatitis B virus (HBV). This can be done by suppressing the secretion of HBV surface antigen (HBsAg). Scientific...

...Hui-Hua Jia; Kai-Wen Li; Qin-Yan Chen; Xue-Yan Wang; Tim J. Harrison; Shu-Jia Liang; Qing-Li Yang; Chao Wang; Li-Ping Hu; Chuang-Chuang Ren; Zhong-Liao Fang Objectives: We aimed to determine the prevalence of hepatitis B virus (HBV) drug-resistant mutations in patients co- infected with HBV/human...

... 2007 and January 2016. Acute viral infections were observed in 23 (19.8%) patients with HEV, 49 (42.2%) patients with hepatitis A virus, 28 (24.1%) patients with hepatitis B virus, and 16 (13.8%) patients with hepatitis C virus. Results: The incidence of acute HEV infection was higher among older...

...Nimisha Harshadrai Bhoola; Anna Kramvis Background: Hepatitis B virus (HBV) is hyperendemic in southern Africa, with subgenotype A1 prevailing. The precore/core (preC/C) region of A1, encoding for hepatitis B e antigen (HBeAg), has unique sequence characteristics, differentiating it from...

... and HBsAg asymptomatic carriers among individuals infected with hepatitis B virus (HBV) with basal core promoter (BCP) double mutations (A1762T, G1764A). Methods: iTRAQ and liquid chromatography-tandem mass spectrometry were used to identify differentially expressed protein, and an ELISA test was used...

... with chronic hepatitis B virus (HBV) infection might be related to higher viral load and disease complications. Thereby, whole blood samples of 208 patients (94 chronic HBV-infected patients and 114 HBV immune subjects) were analyzed to investigate the association between IFNG (-5A→G) , IFNA1 (-2C→T...

...Marta Bes; Victor Vargas; Maria Piron; Natalia Casamitjana; Juan Ignacio Esteban; Isabel Campos-Varela; Lluís Puig; Silvia Sauleda Aims: To investigate the influence of IL28B polymorphism in occult hepatitis B infection (OBI) and whether IL28B genetic variants are associated with hepatitis B virus...

... quasispecies should be useful in the clinical management of hepatitis B virus (HBV) infection. Methods: Six treatment-naïve Indonesian patients with chronic HBV infection participated in this study. The polymerase region of the HBV genome, including regions with known drug-resistant mutations, was subjected...

...Haimanti Bhattacharya; Debdutta Bhattacharya; Muruganandam Nagarajan; Rajesh Reesu; Subarna Roy; Purushottaman Sugunan Attayur The aim of this study was to explore the prevalence of basal core promoter (BCP) and precore gene (PC) mutations in hepatitis B virus (HBV) isolates among the Nicobarese...

..., instructions or products referred to in the content or advertisements. Hepatitis B virus Lamivudine resistance Adefovir Combination therapy A persistently high level of serum hepatitis B virus (HBV) DNA is associated with an increased risk of cirrhosis, hepatocellular carcinoma and liver...

...Adam Gehring; Antonio Bertoletti; John E. Tavis In this review we will focus on host factors known to impact hepatitis B virus (HBV) replication as current or potential targets for therapeutic intervention. Some immunotherapeutic strategies will be discussed because they have the potential...

...Hans L. Tillmann; Keyur Patel Although new hepatitis B virus (HBV) infections are decreasing due to improving vaccination coverage, patients without vaccination coverage can still suffer from manifestation of acute hepatitis B with jaundice and (although rarely) liver failure. No treatment...

... and the highly specific viral and cellular factors involved in its entry, hepatitis B virus (HBV) is an ideal candidate for entry inhibition. Hepatitis B immunoglobulins neutralize infection by binding to the S-domain of HBV surface proteins and are used to prevent reinfection of the graft after liver...

...Dieter Glebe; Andreas Geipel Currently available antiviral therapies specifically target viral replication by blocking reverse transcription with orally given nucleos(t)ide analogues and are able to specifically suppress viral replication. The unique replication strategy of hepatitis B virus (HBV...

... on differentiated hepatocytes for replication. Hepatitis B virus (HBV) is the prototype of the Hepadnaviridae. HBV can persist in infected hepatocytes and has evolved elaborate strategies to evade the immune system. HBV replicates like HIV (family of Retroviridae) via reverse transcription. Drugs licensed...