...Jorge Soares; João Vasco Santos; António Sarmento; Altamiro Costa-Pereira Background/Aims: Spontaneous viral clearance of the chronic hepatitis C virus (HCV) in human immunodeficiency virus (HIV)-infected patients is a rare event. We aimed to identify the clinical, therapeutic, demographic...

... substitutions (RASs) reduce HCV susceptibility to protease inhibitors. Little is known about NS3 RASs in viral isolates from the liver of chronic hepatitis C (CHC) patients infected with HCV genotype-1a (G1a). Aim: The objective of this work was to study NS3 variability in isolates from the serum and liver...

...Hyun Jung Lee; Jong Eun Yeon; Eileen L. Yoon; Sang Jun Suh; Keunhee Kang; Hae Rim Kim; Seong Hee Kang; Yang Jae Yoo; Jihye Je; Ji Hoon Kim; Yeon Seok Seo; Hyung Joon Yim; Kwan Soo Byun Objectives: Interferon (IFN)-based therapy for chronic hepatitis C (CHC) is cost-effective and is associated...

...Hidenori Toyoda; Takashi Kumada; Noritomo Shimada; Koichi Takaguchi; Tatsuya Ide; Michio Sata; Hiroyuki Ginba; Kazuhiro Matsuyama; Namiki Izumi Objective: Some patients with chronic hepatitis C virus (HCV) infection fail to achieve complete early virologic response (EVR) despite a marked decrease...

...Tanja Selic Kurincic; Gorazd Lesnicar; Mario Poljak; Jelka Meglic Volkar; Mojca Rajter; Janja Prah; Zvonko Baklan; Tadeja Kotar; Mojca Maticic Objectives: The combination of pegylated interferon-α and ribavirin is a standard-of-care (SOC) treatment for chronic hepatitis C (CHC), and it achieves...

... significant for multivariate analysis. Chronic hepatitis C Virologic response Sustained virologic response Treatment-naïve Genotype 1 Peginterferon Ribavirin Positive predictive value Negative predictive value Standard of care (SOC) therapy for patients with chronic hepatitis C virus...

... levels in chronic hepatitis C patients treated with pegylated interferon + ribavirin were evaluated in order to envision a combined use of the two assays in therapy monitoring. HCV core antigen levels by a chemiluminescent immunoassay (Abbott ARCHITECT) and HCV-RNA levels by branched DNA (bDNA) or real...

... studied the alteration of the Treg ratio in peripheral blood mononuclear cells (PBMCs) from chronic hepatitis C patients during combination therapy compared with the Treg ratio in liver-infiltrating lymphocytes (LILs) before therapy. Method: The study group consisted of 20 patients who were treatment...

... interferon-α 2b (PEG-IFN-α 2b ) + ribavirin for the initial treatment of chronic hepatitis C. Methods: A total of 126 treatment-naive patients (29.4% genotype 1, 70.6% genotype non-1) were treated with PEG-IFN-α 2a 180 µg/week (group A, n = 79) or PEG-IFN-α 2b 1.5 µg/kg/week (group B, n = 47) with ribavirin...

...-IFN) and ribavirin (RBV) combination therapy for chronic hepatitis C (CHC) and examined its correlation with serum alanine aminotransferase (ALT) levels during therapy and response to the therapy. Methods: A total of 175 patients with CHC received the combination therapy. Correlations between serum...

... for the retreatment of chronic hepatitis C patients with genotype 1b and high viral loads, whose hepatitis C virus was not eradicated by earlier IFN therapy or by pegylated IFN plus ribavirin (PEG-IFN/RBV) combination therapy. In this study, we assessed the early viral dynamics of 9 patients with non-sustained...

...Koji Ishii; Mie Shinohara; Misato Sawa; Michio Kogame; Katsuya Higami; Masanari Sano; Toshisuke Morita; Yasukiyo Sumino Background/Aim: When patients with chronic hepatitis C (CHC) are treated with interferon (IFN)-based therapy, achieving serum HCV-RNA negativity by week 12 (early viral response...

... Chronic hepatitis C Liver cirrhosis Hepatocellular carcinoma Indonesia Original Paper Intervirology 2008;51:410 416 DOI: 10.1159/000205515 Received: April 29, 2008 Accepted after revision: January 19, 2009 Published online: March 4, 2009 Hepatitis C Virus Genotype in Blood Donors and Associated...

.... Occult hepatitis B virus infection Chronic hepatitis C Liver cirrhosis Hepatocellular carcinoma Electron microscopy Original Paper Intervirology 2008;51:352 361 DOI: 10.1159/000187720 Received: August 28, 2006 Accepted after revision: October 22, 2008 Published online: January 7, 2009 Influence...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute hepatitis C Chronic hepatitis C HCV carrier Diagnosis HCV-RNA...

...Miki Nagashima; Masatoshi Kudo; Hobyung Chung; Emi Ishikawa; Tatsuo Inoue; Tatsuya Nakatani; Kensaku Dote Objective: Persistently elevated serum alanine aminotransferase (ALT) levels have been observed in chronic hepatitis C (CHC) patients during pegylated interferon (PEG-IFN) therapy. We...

... in combination therapy of peginterferon and ribavirin for chronic hepatitis C. Methods: Inclusion criteria were hepatitis C virus (HCV) genotype 1b, serum HCV RNA level of ≧100 KIU/ml, dose reduction of peginterferon and/or ribavirin between the first 4 weeks and 20 weeks after the initiation of treatment. 164...

...) against ribavirin (RBV)-associated hemolytic anemia during the first 12 weeks in chronic hepatitis C virus (HCV) combination therapy. Methods: This study was a prospective open-label, randomized controlled trial. 100 HCV patients were randomized to either the EPA group (n = 49) or non-EPA group (n = 51...

... Naohide Tanaka Yasuyuki Arakawa Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan Key Words Irregular regeneration of hepatocytes Irregular regeneration score Interferon Hepatocellular carcinoma Chronic hepatitis C Abstract We...

... and interferon-stimulated genes and response to interferon therapy for genotype 1b chronic hepatitis C. Methods: Forty-four patients with genotype 1b chronic hepatitis C who underwent liver biopsy and then received interferon therapy participated in this study. Pretreatment intrahepatic mRNA levels of interferon...