... that NDV infection leads to conformational change of Bax protein. This is associated with the translocation of Bax from the cytoplasm to mitochondria and the release of cytochrome c into the cytoplasm. Interestingly, the level of Bcl-2 protein was not affected by NDV treatment. Conclusion: We have shown...

...John Jenn-Yenn Lu; Jong-Ding Lay Aims: To examine the tumor-forming in nude mice of human epithelial cells co-expressed Bcl-2 and EBV LMP-1 ability, the phenotype of tumor cells and their expression of oncogenes and tumor-suppressor genes. Methods: Following an in vivo tumorigenesis test in nude...

...Lin Zheng; Yida Yang; Lu Guocai; C. David Pauza; Maria S. Salvato Objective: To investigate the effect of HIV Tat protein on Bcl-2 expression in human monocytes, and observe apoptosis of Tat-stimulated monocytes induced by TNF-α-related apoptosis-induced ligand (TRAIL). Methods: Western blot...

...Tracey Williams; Darleen Sale; Sheila Ann Hazlewood The Epstein-Barr virus (EBV) protein BHRF1 ( Bam HI rightward reading frame 1) was the first viral member of the Bcl-2 family of apoptosis-regulating proteins described. In vitro studies imply that BHRF1 is dispensable for virus-induced cellular...