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Journal Articles

Efficacy and Anticarcinogenic Activity of Ribavirin Combination Therapy for Hepatitis C Virus-Related Compensated Cirrhosis

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Norio Akuta, Fumitaka Suzuki, Yuya Seko, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 56 (1): 37–45.
https://doi.org/10.1159/000342746
Published Online: 04 October 2012
View articletitled, Efficacy and Anticarcinogenic Activity of Ribavirin Combination Therapy for Hepatitis C Virus-Related Compensated Cirrhosis
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Journal Articles

Amino Acid Substitutions in the Hepatitis C Virus Core Region and Lipid Metabolism Are Associated with Hepatocarcinogenesis in Nonresponders to Interferon plus Ribavirin Combination Therapy

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Yuya Seko, Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 56 (1): 13–21.
https://doi.org/10.1159/000339993
Published Online: 16 August 2012
View articletitled, Amino Acid Substitutions in the Hepatitis C Virus Core Region and Lipid Metabolism Are Associated with Hepatocarcinogenesis in Nonresponders to Interferon plus Ribavirin Combination Therapy
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Journal Articles

Amino Acid Substitution in HCV Core Region and Genetic Variation near the IL28B Gene Affect Viral Dynamics during Telaprevir, Peginterferon and Ribavirin Treatment

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Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Kazuaki Chayama, Yusuke Nakamura, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 55 (6): 417–425.
https://doi.org/10.1159/000323526
Published Online: 08 June 2012
View articletitled, Amino Acid Substitution in HCV Core Region and Genetic Variation near the IL28B Gene Affect Viral Dynamics during Telaprevir, Peginterferon and Ribavirin Treatment
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Journal Articles

Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy

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Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Kazuaki Chayama, Yusuke Nakamura, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 55 (3): 231–241.
https://doi.org/10.1159/000328327
Published Online: 05 July 2011
View articletitled, Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy
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Journal Articles

Extending Combination Therapy with Peginterferon plus Ribavirin for Genotype 2 Chronic Hepatitis C Virological Responders: A Pilot Study of 7 Cases

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Norio Akuta, Fumitaka Suzuki, Yasuji Arase, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2010) 53 (3): 188–192.
https://doi.org/10.1159/000289343
Published Online: 03 March 2010
View articletitled, Extending Combination Therapy with Peginterferon plus Ribavirin for Genotype 2 Chronic Hepatitis C Virological Responders: A Pilot Study of 7 Cases
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Journal Articles

Virological and Biochemical Features in Elderly HCV Patients with Hepatocellular Carcinoma: Amino Acid Substitutions in HCV Core Region as Predictor of Mortality after First Treatment

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Suguru Ogura, Norio Akuta, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 52 (4): 179–188.
https://doi.org/10.1159/000225193
Published Online: 17 June 2009
View articletitled, Virological and Biochemical Features in Elderly HCV Patients with Hepatocellular Carcinoma: Amino Acid Substitutions in HCV Core Region as Predictor of Mortality after First Treatment
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Journal Articles

Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 2a High Viral Load and Virological Response to Interferon-Ribavirin Combination Therapy

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Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 52 (6): 301–309.
https://doi.org/10.1159/000235909
Published Online: 05 May 2009
View articletitled, Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 2a High Viral Load and Virological Response to Interferon-Ribavirin Combination Therapy
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Journal Articles

An Open Pilot Study Exploring the Efficacy of Fluvastatin, Pegylated Interferon and Ribavirin in Patients with Hepatitis C Virus Genotype 1b in High Viral Loads

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Hitomi Sezaki, Fumitaka Suzuki, Norio Akuta, Hiromi Yatsuji, Tetsuya Hosaka, Masahiro Kobayashi, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Yuzo Miyakawa, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 52 (1): 43–48.
https://doi.org/10.1159/000213504
Published Online: 17 April 2009
View articletitled, An Open Pilot Study Exploring the Efficacy of Fluvastatin, Pegylated Interferon and Ribavirin in Patients with Hepatitis C Virus Genotype 1b in High Viral Loads
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Journal Articles

Virological Response and Hepatocarcinogenesis in Lamivudine-Resistant Hepatitis B Virus Genotype C Patients Treated with Lamivudine plus Adefovir Dipivoxil

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Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 51 (6): 385–393.
https://doi.org/10.1159/000203283
Published Online: 20 February 2009
View articletitled, Virological Response and Hepatocarcinogenesis in Lamivudine-Resistant Hepatitis B Virus Genotype C Patients Treated with Lamivudine plus Adefovir Dipivoxil
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Journal Articles

Lipiodol and Dye at the Site of Ablation Decreases during RFA

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Miharu Hirakawa, Kenji Ikeda, Yusuke Kawamura, Masahiro Kobayashi, Tetsuya Hosaka, Hiromi Yatsuji, Hitomi Sezaki, Norio Akuta, Satoshi Saitoh, Fumitaka Suzuki, Yoshiyuki Suzuki, Yasuji Arase, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 51 (5): 362–368.
https://doi.org/10.1159/000187721
Published Online: 07 January 2009
View articletitled, Lipiodol and Dye at the Site of Ablation Decreases during RFA
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Journal Articles

The Efficacy of 24-Week Interferon Monotherapy for Type C Liver Cirrhosis in Japanese Patients with Genotype 1b and Low Virus Load

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Yasuji Arase, Fumitaka Suzuki, Hitomi Sezaki, Yusuke Kawamura, Yoshiyuki Suzuki, Masahiro Kobayashi, Norio Akuta, Tetsuya Hosaka, Hiromi Yatsuji, Miharu Hirakawa, Mariko Kobayashi, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2008) 51 (4): 265–269.
https://doi.org/10.1159/000160216
Published Online: 07 October 2008
View articletitled, The Efficacy of 24-Week Interferon Monotherapy for Type C Liver Cirrhosis in Japanese Patients with Genotype 1b and Low Virus Load
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Journal Articles

Efficacy in Patients with Dose Reduction in Combination Therapy of Peginterferon and Ribavirin for Chronic Hepatitis C

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Yasuji Arase, Fumitaka Suzuki, Hitomi Sezaki, Yusuke Kawamura, Yoshiyuki Suzuki, Masahiro Kobayashi, Norio Akuta, Tetsuya Hosaka, Hiromi Yatsuji, Miharu Hirakawa, Mariko Kobayashi, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2008) 51 (1): 1–6.
https://doi.org/10.1159/000118789
Published Online: 29 February 2008
View articletitled, Efficacy in Patients with Dose Reduction in Combination Therapy of Peginterferon and Ribavirin for Chronic Hepatitis C
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Journal Articles

Prediction of Response to Pegylated Interferon and Ribavirin in Hepatitis C by Polymorphisms in the Viral Core Protein and Very Early Dynamics of Viremia

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Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Yuzo Miyakawa, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2007) 50 (5): 361–368.
https://doi.org/10.1159/000107707
Published Online: 29 August 2007
View articletitled, Prediction of Response to Pegylated Interferon and Ribavirin in Hepatitis C by Polymorphisms in the Viral Core Protein and Very Early Dynamics of Viremia
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Journal Articles

Long-Term Presence of HBV in the Sera of Chronic Hepatitis B Patients with HBsAg Seroclearance

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Yasuji Arase, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Junko Sato, Mariko Kobayashi, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2007) 50 (3): 161–165.
https://doi.org/10.1159/000098958
Published Online: 26 January 2007
View articletitled, Long-Term Presence of HBV in the Sera of Chronic Hepatitis B Patients with HBsAg Seroclearance
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Journal Articles

Long-Term Outcome after Interferon Therapy in Elderly Patients with Chronic Hepatitis C

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Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Rikako Koyama, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2006) 50 (1): 16–23.
https://doi.org/10.1159/000096308
Published Online: 24 November 2006
View articletitled, Long-Term Outcome after Interferon Therapy in Elderly Patients with Chronic Hepatitis C
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Journal Articles

Long-Term Follow-Up of HBeAg-Positive Young Adult Japanese Patients Treated with Corticosteroid Withdrawal Therapy for Chronic Hepatitis B

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Hitomi Sezaki, Fumitaka Suzuki, Tetsuya Hosaka, Norio Akuta, Takashi Someya, Masahiro Kobayashi, Yoshiyuki Suzuki, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2006) 49 (6): 339–345.
https://doi.org/10.1159/000095153
Published Online: 06 October 2006
View articletitled, Long-Term Follow-Up of HBeAg-Positive Young Adult Japanese Patients Treated with Corticosteroid Withdrawal Therapy for Chronic Hepatitis B
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Journal Articles

Efficacy of Interferon Therapy in Elderly Patients with Chronic Hepatitis C

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Rikako Koyama, Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2006) 49 (3): 121–126.
https://doi.org/10.1159/000089372
Published Online: 23 January 2006
View articletitled, Efficacy of Interferon Therapy in Elderly Patients with Chronic Hepatitis C
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Anticarcinogenic Impact of Interferon on Patients with Chronic Hepatitis C: A Large-Scale Long-Term Study in a Single Center

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Kenji Ikeda, Yasuji Arase, Satoshi Saitoh, Masahiro Kobayashi, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Norio Akuta, Fumitaka Suzuki, Yoshiyuki Suzuki, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 49 (1-2): 82–90.
https://doi.org/10.1159/000087268
Published Online: 16 September 2005
View articletitled, Anticarcinogenic Impact of Interferon on Patients with Chronic Hepatitis C: A Large-Scale Long-Term Study in a Single Center
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Journal Articles

Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 1b High Viral Load and Non-Virological Response to Interferon-Ribavirin Combination Therapy

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Norio Akuta, Fumitaka Suzuki, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Sachiyo Watahiki, Junko Sato, Marie Matsuda, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 48 (6): 372–380.
https://doi.org/10.1159/000086064
Published Online: 08 July 2005
View articletitled, Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 1b High Viral Load and Non-Virological Response to Interferon-Ribavirin Combination Therapy
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Journal Articles

Usefulness of the Serum KL-6 Assay in Patients with Hepatitis C Virus

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Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 48 (6): 400–404.
https://doi.org/10.1159/000086067
Published Online: 08 July 2005
View articletitled, Usefulness of the Serum KL-6 Assay in Patients with Hepatitis C Virus
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