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Mariko Kobayashi
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Journal Articles

Efficacy and Anticarcinogenic Activity of Ribavirin Combination Therapy for Hepatitis C Virus-Related Compensated Cirrhosis

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Norio Akuta, Fumitaka Suzuki, Yuya Seko, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 56 (1): 37–45.
https://doi.org/10.1159/000342746
Published Online: 04 October 2012
View articletitled, Efficacy and Anticarcinogenic Activity of Ribavirin Combination Therapy for Hepatitis C Virus-Related Compensated Cirrhosis
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Journal Articles

Amino Acid Substitutions in the Hepatitis C Virus Core Region and Lipid Metabolism Are Associated with Hepatocarcinogenesis in Nonresponders to Interferon plus Ribavirin Combination Therapy

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Yuya Seko, Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 56 (1): 13–21.
https://doi.org/10.1159/000339993
Published Online: 16 August 2012
View articletitled, Amino Acid Substitutions in the Hepatitis C Virus Core Region and Lipid Metabolism Are Associated with Hepatocarcinogenesis in Nonresponders to Interferon plus Ribavirin Combination Therapy
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Journal Articles

Amino Acid Substitution in HCV Core Region and Genetic Variation near the IL28B Gene Affect Viral Dynamics during Telaprevir, Peginterferon and Ribavirin Treatment

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Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Kazuaki Chayama, Yusuke Nakamura, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 55 (6): 417–425.
https://doi.org/10.1159/000323526
Published Online: 08 June 2012
View articletitled, Amino Acid Substitution in HCV Core Region and Genetic Variation near the IL28B Gene Affect Viral Dynamics during Telaprevir, Peginterferon and Ribavirin Treatment
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Journal Articles

Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy

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Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Kazuaki Chayama, Yusuke Nakamura, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2012) 55 (3): 231–241.
https://doi.org/10.1159/000328327
Published Online: 05 July 2011
View articletitled, Amino Acid Substitution in HCV Core/NS5A Region and Genetic Variation Near IL28B Gene Affect Treatment Efficacy to Interferon plus Ribavirin Combination Therapy
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Journal Articles

Extending Combination Therapy with Peginterferon plus Ribavirin for Genotype 2 Chronic Hepatitis C Virological Responders: A Pilot Study of 7 Cases

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Norio Akuta, Fumitaka Suzuki, Yasuji Arase, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2010) 53 (3): 188–192.
https://doi.org/10.1159/000289343
Published Online: 03 March 2010
View articletitled, Extending Combination Therapy with Peginterferon plus Ribavirin for Genotype 2 Chronic Hepatitis C Virological Responders: A Pilot Study of 7 Cases
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Journal Articles

Virological and Biochemical Features in Elderly HCV Patients with Hepatocellular Carcinoma: Amino Acid Substitutions in HCV Core Region as Predictor of Mortality after First Treatment

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Suguru Ogura, Norio Akuta, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Tetsuya Hosaka, Masahiro Kobayashi, Fumitaka Suzuki, Yoshiyuki Suzuki, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 52 (4): 179–188.
https://doi.org/10.1159/000225193
Published Online: 17 June 2009
View articletitled, Virological and Biochemical Features in Elderly HCV Patients with Hepatocellular Carcinoma: Amino Acid Substitutions in HCV Core Region as Predictor of Mortality after First Treatment
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Journal Articles

Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 2a High Viral Load and Virological Response to Interferon-Ribavirin Combination Therapy

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Norio Akuta, Fumitaka Suzuki, Miharu Hirakawa, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 52 (6): 301–309.
https://doi.org/10.1159/000235909
Published Online: 05 May 2009
View articletitled, Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 2a High Viral Load and Virological Response to Interferon-Ribavirin Combination Therapy
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Journal Articles

Virological Response and Hepatocarcinogenesis in Lamivudine-Resistant Hepatitis B Virus Genotype C Patients Treated with Lamivudine plus Adefovir Dipivoxil

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Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2009) 51 (6): 385–393.
https://doi.org/10.1159/000203283
Published Online: 20 February 2009
View articletitled, Virological Response and Hepatocarcinogenesis in Lamivudine-Resistant Hepatitis B Virus Genotype C Patients Treated with Lamivudine plus Adefovir Dipivoxil
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Journal Articles

The Efficacy of 24-Week Interferon Monotherapy for Type C Liver Cirrhosis in Japanese Patients with Genotype 1b and Low Virus Load

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Yasuji Arase, Fumitaka Suzuki, Hitomi Sezaki, Yusuke Kawamura, Yoshiyuki Suzuki, Masahiro Kobayashi, Norio Akuta, Tetsuya Hosaka, Hiromi Yatsuji, Miharu Hirakawa, Mariko Kobayashi, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2008) 51 (4): 265–269.
https://doi.org/10.1159/000160216
Published Online: 07 October 2008
View articletitled, The Efficacy of 24-Week Interferon Monotherapy for Type C Liver Cirrhosis in Japanese Patients with Genotype 1b and Low Virus Load
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Journal Articles

Efficacy in Patients with Dose Reduction in Combination Therapy of Peginterferon and Ribavirin for Chronic Hepatitis C

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Yasuji Arase, Fumitaka Suzuki, Hitomi Sezaki, Yusuke Kawamura, Yoshiyuki Suzuki, Masahiro Kobayashi, Norio Akuta, Tetsuya Hosaka, Hiromi Yatsuji, Miharu Hirakawa, Mariko Kobayashi, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2008) 51 (1): 1–6.
https://doi.org/10.1159/000118789
Published Online: 29 February 2008
View articletitled, Efficacy in Patients with Dose Reduction in Combination Therapy of Peginterferon and Ribavirin for Chronic Hepatitis C
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Journal Articles

Prediction of Response to Pegylated Interferon and Ribavirin in Hepatitis C by Polymorphisms in the Viral Core Protein and Very Early Dynamics of Viremia

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Norio Akuta, Fumitaka Suzuki, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Masahiro Kobayashi, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Yuzo Miyakawa, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2007) 50 (5): 361–368.
https://doi.org/10.1159/000107707
Published Online: 29 August 2007
View articletitled, Prediction of Response to Pegylated Interferon and Ribavirin in Hepatitis C by Polymorphisms in the Viral Core Protein and Very Early Dynamics of Viremia
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Journal Articles

Long-Term Presence of HBV in the Sera of Chronic Hepatitis B Patients with HBsAg Seroclearance

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Yasuji Arase, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Junko Sato, Mariko Kobayashi, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2007) 50 (3): 161–165.
https://doi.org/10.1159/000098958
Published Online: 26 January 2007
View articletitled, Long-Term Presence of HBV in the Sera of Chronic Hepatitis B Patients with HBsAg Seroclearance
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Journal Articles

Long-Term Outcome after Interferon Therapy in Elderly Patients with Chronic Hepatitis C

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Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Rikako Koyama, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2006) 50 (1): 16–23.
https://doi.org/10.1159/000096308
Published Online: 24 November 2006
View articletitled, Long-Term Outcome after Interferon Therapy in Elderly Patients with Chronic Hepatitis C
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Journal Articles

Efficacy of Interferon Therapy in Elderly Patients with Chronic Hepatitis C

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Rikako Koyama, Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2006) 49 (3): 121–126.
https://doi.org/10.1159/000089372
Published Online: 23 January 2006
View articletitled, Efficacy of Interferon Therapy in Elderly Patients with Chronic Hepatitis C
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Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 1b High Viral Load and Non-Virological Response to Interferon-Ribavirin Combination Therapy

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Norio Akuta, Fumitaka Suzuki, Hitomi Sezaki, Yoshiyuki Suzuki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Sachiyo Watahiki, Junko Sato, Marie Matsuda, Mariko Kobayashi, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 48 (6): 372–380.
https://doi.org/10.1159/000086064
Published Online: 08 July 2005
View articletitled, Association of Amino Acid Substitution Pattern in Core Protein of Hepatitis C Virus Genotype 1b High Viral Load and Non-Virological Response to Interferon-Ribavirin Combination Therapy
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Journal Articles

Usefulness of the Serum KL-6 Assay in Patients with Hepatitis C Virus

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Yasuji Arase, Kenji Ikeda, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 48 (6): 400–404.
https://doi.org/10.1159/000086067
Published Online: 08 July 2005
View articletitled, Usefulness of the Serum KL-6 Assay in Patients with Hepatitis C Virus
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Virological and Biochemical Relapse after Discontinuation of Lamivudine Monotherapy for Chronic Hepatitis B in Japan: Comparison with Breakthrough Hepatitis during Long-Term Treatment

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Norio Akuta, Fumitaka Suzuki, Mariko Kobayashi, Marie Matsuda, Junko Sato, Yoshiyuki Suzuki, Hitomi Sezaki, Tetsuya Hosaka, Takashi Someya, Masahiro Kobayashi, Satoshi Saitoh, Yasuji Arase, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 48 (2-3): 174–182.
https://doi.org/10.1159/000081746
Published Online: 24 March 2005
View articletitled, Virological and Biochemical Relapse after Discontinuation of Lamivudine Monotherapy for Chronic Hepatitis B in Japan: Comparison with Breakthrough Hepatitis during Long-Term Treatment
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Journal Articles

Significance of Serum Ribavirin Concentration in Combination Therapy of Interferon and Ribavirin for Chronic Hepatitis C

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Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2005) 48 (2-3): 138–144.
https://doi.org/10.1159/000081741
Published Online: 24 March 2005
View articletitled, Significance of Serum Ribavirin Concentration in Combination Therapy of Interferon and Ribavirin for Chronic Hepatitis C
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Journal Articles

Interferon Therapy for 2 Years or Longer Reduces the Incidence of Hepatocarcinogenesis in Patients with Chronic Hepatitis C Viral Infection

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Yasuji Arase, Kenji Ikeda, Akihito Tsubota, Fumitaka Suzuki, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Hitomi Sezaki, Mariko Kobayashi, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2004) 47 (6): 355–361.
https://doi.org/10.1159/000080880
Published Online: 26 November 2004
View articletitled, Interferon Therapy for 2 Years or Longer Reduces the Incidence of Hepatocarcinogenesis in Patients with Chronic Hepatitis C Viral Infection
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Journal Articles

Sustained Negativity for HCV-RNA over 24 or More Months by Long-Term Interferon Therapy Correlates with Eradication of HCV in Patients with Hepatitis C Virus Genotype 1b and High Viral Load

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Yasuji Arase, Fumitaka Suzuki, Akihito Tsubota, Yoshiyuki Suzuki, Satoshi Saitoh, Masahiro Kobayashi, Norio Akuta, Takashi Someya, Tetsuya Hosaka, Mariko Kobayashi, Hitomi Sezaki, Kenji Ikeda, Hiromitsu Kumada
Journal: Intervirology
Intervirology (2004) 47 (1): 19–25.
https://doi.org/10.1159/000076638
Published Online: 26 March 2004
View articletitled, Sustained Negativity for HCV-RNA over 24 or More Months by Long-Term Interferon Therapy Correlates with Eradication of HCV in Patients with Hepatitis C Virus Genotype 1b and High Viral Load
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