Examination of renal glomeruli from two patients with African Burkitt’s lymphoma revealed host immunoglobulin G (IgG) and the third component of complement (C3), but not fibrinogen or albumin, along the glomerular basement membrane and mesangia in a granular, discontinuous pattern characteristic of immune complex deposits. Elution and subsequent immunologic assays indicated that the IgG bound to the glomeruli contained antibodies to viral capsid antigens (VCA) and early antigens (EA), but not detectable anti-body(s) to complement-fixing nuclear antigens (EBNA) or membrane antigens (MA) of Epstein-Barr virus (EBV). In contrast, serum contained antibodies to VCA, EA, EBNA and MA of EBV. Absorption of Ig obtained from the serum and renal eluate with EBV antigens revealed the presence of EBV antibodies in the renal glomeruli. Study of selected sera from patients with Burkitt’s lymphoma indicated that 9 out of 15, or 60%, contained evidence of complement-binding complexes.

Keywords:
Epstein-Barr-virus-antibody immune complexes, African Burkitt’s patients
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© 1974 S. Karger AG, Basel
1974
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