Cytomegalovirus(CMV)-specific lymphocyte proliferation in vitro was tested in the presence or absence of CMV-specific antibodies. CMV antibodies clearly enhanced CMV-specific lymphocyte proliferation but not lymphocyte proliferation induced by other antigens. Enhancement was most consistently found with cell-bound CMV antigens and often with cell-free CMV as stimulating antigen. CMV antibodies only stimulated when they were added at an early stage of the lymphocyte culture, and the stimulating effect was most pronounced at optimal and suboptimal antigen concentrations. Our data suggest that CMV antibodies stimulate CMV-specific lymphocyte proliferation at the level of antigen presentation.

Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.