Competition radioimmunoassays for the 27,000 molecular weight (p27) major internal protein and the low-molecular-weight 10,000–12,000 (p10–12) polypeptides of the primate type-D retroviruses, Mason-Pfizer virus (MPV) and langur virus (LV), were established. Type-D isolates from various primate and human tumor cells were examined in both these assays. There were no detectable immunological differences between MPV and two type-D retroviruses previously reported to be isolated from human cell lines (HeLa and AO). Type-D retroviruses isolated from human T9 and J96 cells (cell lines derived from human leukemic cells), however, were clearly distinguishable from both MPV and LV in their respective p10–12 radioimmunoassays. These assays thus demonstrate that type-D retroviruses isolated from some human cells may differ immunologically from morphologically similar viruses isolated from nonhuman primates.

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