The testis has been shown to be a privileged site for transplantation of allogenic islets in rodents. Pancreatic islets transplantation is a potential attractive treatment for type 1 diabetes. The aim of the precent study was to assess whether the testis of Balb/c mice would have an immune privilege nature as a host for islets transplantation. The isolated guinea pigs (Cavia cobaya) pancreatic cells (500 cells/20 g of recipient body weight) were transplanted into the testis or peritoneum of alloxan-induced diabetic Balb/c mice. The results showed that intratesticular xeno-transplanted islets were able to survive up to 14 days significantly (P<0.05) longer compared to those of islets transplanted intra peritoneally. The data suggest that testis of Balb/c mice can be used as a model for immune privilege- and transplantation studies.

Keywords:
xeno-transplantation, testis, pancreatic islets, alloxan diabetes
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2012
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