Insulin resistance is an important pathogenic factor in type 2 diabetes patents. An easy and efficiency measurement predicting insulin resistance; which can be done easily by type 2 patients is desired. The aim of this study is to examine whether waist circumference is a better predictor of insulin resistance in type 2 diabetes than body mass index (BMI). From a population of 1356 registered diabetic patients, 144 who met (1) aged between 30 and 75 years, (2) being Chinese, (3) having had type 2 diabetes for more than one year, (4) having been taking gliclazide and metformin for more than 6 months were enrolled in this study. The main outcome evaluated is the associations of HOMA insulin resistance index (HOMA index); which were assessed using multiple linear regression analysis. The coefficients of multiple regression analysis with stepwise model showed that waist circumference ( = 0.35, p < 0.001) but not BMI ( = 0.01, p= 0.94), and hemoglobulin A1C% (HbA1C) ( = 0.25, p = 0.01) were the main predictors of HOMA index. These initial findings indicate that waist circumference is a better predictor of insulin resistance in type 2 diabetes than BMI.

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