Chemotactic reactivity of eosinophils obtained from the bone marrow (BM-Eo) of cyclophosphamide-treated, Toxocara canis-infected mice was compared to that of eosinophils obtained from the peritoneal cavity (PEC-Eo). BM-Eo responded well to alanyl-tetrapeptide, a synthetic eosinophil chemotactic factor of anaphylaxis (ECF-A), whereas PEC-Eo did not. Both BM-Eo and PEC-Eo showed almost equally high chemotactic reactivity to parasite-derived ECF, ECF lymphokine and complement-derived ECF. Chemotactic reactivity of BM-Eo to synthetic ECF-A was deactivated by preincubation with ECF-A. Unresponsiveness of PEC-Eo to synthetic ECF-A could be explained by chemotactic deactivation by ECF-A, because an ECF-A-like substance was detected in the ascitic fluid; this substance could deactivate the chemotactic reactivity of BM-Eo to synthetic ECF-A. From these results, BM-Eo are naive and seem to be a good indicator for eosinophilotaxis and its modulation.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.