In a recent study it was found that children with recurrent acute otitis media (rAOM), in contrast to healthy children, frequently lack detectable antipneumococcal IgG antibodies against capsular types 6A and 19F. In children with rAOM, the concentrations of antibodies against type 6A polysaccharide remained low even after the period of rAOM had ceased. Antibody levels against various pneumococcal capsular polysaccharides were determined in otitis-prone and healthy members of 19 families. 25 children with a history of rAOM (mean age 7.2 years) and their parents, one of whom in each family had had rAOM during childhood, were investigated. Compared to the parents, the rAOM children had lower concentrations of IgG antibodies against the pneumococcal types 6A, 14, 19F and 23F and of IgA antibodies against type 23F. Compared to their parents, the rAOM children had higher concentrations of IgM antibodies against types 3 and 23F. ‘Healthy parents’ did not differ from ‘rAOM parents’ in IgG antibody levels against any of the pneumococcal capsular polysaccharides investigated. The findings indicate that rAOM occurs in individuals with a delayed rather than with a persisting inability to mount an adequate antibody response against the offending pneumococci.

This content is only available via PDF.
© 1984 S. Karger AG, Basel
1984
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.