The present animal experiments revealed that repeated intra-articular administration of Α2-macroglobulin trypsin complexes caused a rheumatoid-like synovitis in not preimmunized rabbits. In early stages of synovitis, acute to subacute pathomorphological alterations were observed. In later stages, the chronic infiltration was accomplished by early onset of fibroplasia in some experimental joints. Similar lesions were caused by administration of methylamine-treated Α2-macroglobulin, an inactive Α2-macroglobulin (Α2-M), very like that produced in the trapping of a proteinase. In contrast, administration of native plasma Α2-M was ineffective, whereas active trypsin produced moderate inflammation. It is felt that the present experimental model resembles immunopathological processes in human arthritides, where the occurrence of Α2-M·proteinase complexes was verified.

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© 1983 S. Karger AG, Basel
1983
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