A strong delayed-type footpad reaction was established in mice using azobenzenearsonate-acetyl bovine serum albumin (ABA-AcBSA) as an antigen. Male ddY/S mice were sensitized by subcutaneous injection of 100 μ l of Freund’s complete adjuvant – saline (1:1) emulsion containing 100 μ g of the antigen and challenged by subcutaneous injection of 2.5 μ l of Freund’s incomplete adjuvant – saline (1:1) emulsion with 2.5 μ g antigen in the footpad on the 10th day after the sensitization. The analysis of the system which fulfilled criteria for delayed-type hypersensitivity with regard to kinetics, passive transfer and histology of the footpad reaction, and the effect of dexamethasone, indomethacin and quinacrine on the footpad reaction were described.

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© 1981 S. Karger AG, Basel
1981
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