Normal and sulphonamide-sensitised mice were made tolerant with 4-sulphanilamido-benzoic-diaminopropyl-carboxymethyl-levan (4-SABA-Le). The tolerance was demonstrably specific for the sulphanilamide moiety of the hapten and extended to related compounds sharing this determinant. Mice sensitised with a 4-SABA-chicken γ-globulin conjugate developed fatal anaphylactic shock after the injection of sulphanilamide or 4-SABA-ovalbumin, whereas allergic mice subsequently tolerised with 4-SABA-Le did not. The tolerance induced was long lasting since mice were still tolerant 7 months after an injection of an optimal dose of tolerogen. Suppressor cells play little or no part in the maintenance of this unresponsive state since even a 10-fold excess of splenic cells from tolerant animals failed to inhibit the responsiveness of 4-SABA-primed cells when they were transferred together into irradiated recipients.

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© 1979 S. Karger AG, Basel
1979
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