Four T-cell lines of mouse origin (EL-4, S-49, R-1, and L-5178Y) with similar characteristics (Thy-1-positive, and PHA-sensitive) were tested for reactivity with various antigens. EL-4 cells alone were shown to form rosettes at 4 °C with thymocytes (positive for either Thy-1.1 or Thy-1.2) and with Thy-1-positive lymph node cells of various mouse strains. Comparable rosette formation did not occur with Thy-1-negative lymphnode cells or red blood cells, nor with rat or rabbit thymocytes. The thymocytes which attached to the tumor cells formed a cluster at one pole of the cell after warming at 37 °C for 10 min. After incubation for 40 min at 37 °C, most of the rosettes disappeared. This process was blocked by sodium azide and dinitrophenol, suggesting that the movement of thymocytes to one pole of the tumor cell and subsequent release are energy-dependent. These results suggest that the EL-4 cell line, originally derived from a carcinogen-induced lymphoma of C57BL/6, may have been an autoimmune lymphoma reactive against T cells.

This content is only available via PDF.
© 1976 S. Karger AG, Basel
1976
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.