An experimental model for studying anaphylactic histamine release from rat peritoneal cells in vitro is described. Rats were sensitized by feeding the infective eggs of Toxocara canis, the antigen being prepared from the infective other anaphylactic systems. Addition of 0.2% inactivated normal rat serum to the incubation media reduced the spontaneous histamine release from 11.5 ± 1.9% to 3.1 ± 1.6% (mean ± SD) of total histamine, whereas the corresponding figure for anaphylactic histamine release was 41.3 ± 19.7%. Both disodium cromoglycate (DSCG) and levamisole produced a dose-related inhibition of histamine release, with DSCG being the more potent drug.

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