Lymphocytes, which had been stimulated in vitro with concanavalin A, were found to be able to give rise to weak graft-versus-host reaction when injected into syngeneic mice. Stimulated lymphocytes also had the ability to enhance 7S antibody production. Stimulation of host 7S antibody-forming cells could be obtained with extracts from the stimulated lymphocytes as well as with fractionated culture medium from the in vitro stimulated lymphocytes. The stimulated lymphocytes incorporated 3H-leucine into two factors with different molecular weights, and stimulation of antibody-forming cells was obtained with the factor showing the highest molecular weight (≥ 75×106 daltons). The results obtained are compatible with the hypothesis that stimulated T cells secrete an antigen nonspecific factor capable of stimulating differentiation of antigen-primed B cells into 7S antibody-forming cells.

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