The relative capacity of parental thymus and spleen cells to induce graft-versus-host reactions (GVHR), as reflected by spleen enlargement and stimulation of antibody formation, was studied in Fl hybrid mice. The relative GVHR-inducing abilities of the two cell types varied considerably, depending on the strain combination employed. The effect of parental lymphoid cells on spleen weight did not parallel their effect on antibody formation. In experiments using high concentrations of parental cells, thymus cells were more efficient than spleen cells as regards stimulation of antibody formation. The results indicate that thymus cells have a marked ability to induce GVHR. It is most unlikely that this ability is dependent upon the presence of contaminating peripheral lymphocytes in the thymus cell preparation used in the experiments.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.