Disodium cromoglycate (DSCG) inhibited rat peritoneal mast cell degranulation induced by anti-rat serum, noradrenaline, imidazole, phospholipase-A, and antigen. Antigen-induced degranulation was also inhibited by theophylline, isoprenaline, and dibutyryl cAMP, whereas ATP-induced degranulation was inhibited by indomethacin but not by DSCG or drugs known to influence the level of intra-cellular cyclic AMP. The inhibition by DSCG of compound 48/80-induced degranulation was shown to be independent of calcium ions. DSCG, isoprenaline, and prostaglandin E1 inhibited the calcium-independent activation stage of phospholipase-A-induced degranulation rather than the calcium-dependent granule extrusion stage. Theophylline-like drugs and dibutyryl cyclic AMP, on the other hand, inhibited degranulation when present in either first or second stage. The rate of development of tolerance to DSCG was also studied and found to be increased by addition of isoprenaline but decreased by addition of theophylline. These results are discussed in terms of the inhibitory activity of DSCG and theophylline-like drugs on cyclic AMP phosphodiesterase.

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© 1974 S. Karger AG, Basel
1974
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