Further evidence is presented indicating that the sensitizing effects of Bordetella pertussis may be mediated by blockade of β-adrenergic receptors of the autonomic nervous system. Both the extracted histamine-sensitizing factor (HSF) of B. pertussis and the β-adrenergic blocking agent, propranolol, were found capable of enhancing the sensitivity of mice to experimental immune hemolytic anemia, hypothermic stress, and bacterial endotoxin. Although pertussis-vaccinated guinea pigs exhibited a slightly higher mortality following histamine challenge, no differences were detected in the respiratory responses (pulmonary compliance and resistance) of pertussis-inoculated and control guinea pigs following histamine. These results indicate that the action of B. pertussis is more selective among species than are the β-adrenergic blocking agents such as propranolol.

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© 1971 S. Karger AG, Basel
1971
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